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BMS 185 Lecture > Lecture 14 (on final) > Flashcards

Lecture 14 (on final) Flashcards

1
Q

Fresh Frozen Plasma (FFP) should be ____________ with the recipient

A

ABO compatible (ignore Rh)

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2
Q

What is the volume range of Fresh Frozen Plasma (FFP) transfused into a patient?

A

50-200mL

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3
Q

What is in Fresh Frozen Plasma (FFP)?

A

Factor VIII, Factor IX, Fibrinogen, Albumin, Globulin

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4
Q

What temperature do you store Fresh Frozen Plasma (FFP)?

A

-20C

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5
Q

What temperature do you keep thawed Fresh Frozen Plasma (FFP)?

A

4C (modern = 5 days; old af = 24 hrs)

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6
Q

When should plasma be frozen?

A

within 8 hrs of collection

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7
Q

What is oncotic pressure?

A

pressure that keeps water in the plasma

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8
Q

Fresh Frozen Plasma (FFP) is hyper____(3) and hypo____(1)

A
  1. hyperosmolal (pressure)
  2. hyperglycemic (glucose)
  3. hypernatremic (sodium)
  4. hypochloremic (chlorine)
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9
Q

What are Fresh Frozen Plasma (FFP) indications (people who would need it???)?

A
  1. single clotting factor deficiency
  2. multiple clotting factors deficiencies (DIC)
  3. massive transfusions
  4. warfarin overdose
  5. hemorrhagic disease of neonates
  6. TTP
  7. liver failure
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10
Q

What is cryoprecipitate?

A

a concentrate of cold and insoluble high-molecular-weight plasma proteins

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11
Q

What is the most common reason for use of cryoprecipitate?

A

fibrinogen replacement

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12
Q

What diseases are treated with cryoprecipitate?

A
  1. Fibrinogen replacement
  2. Factor VIII deficiency (Hemophilia A)
  3. von Willebrand’s Disease
  4. Congenital or acquired fibrinogen defects (dysfibrinogenemia)
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13
Q

How is cryoprecipitate made?

A

precipitates form when frozen plasma is slowly thawed at 1-6C

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14
Q

What blood clotting proteins does cryoprecipitate contain?

A
  1. Fibrinogen
  2. Factor VIII
  3. Facttor XIII
  4. Von Willebrand Factor (VWF)
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15
Q

Can cryoprecipitate be refrozen?

A

no

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16
Q

How long can you store thawed cryoprecipitate?

A

6 hrs

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17
Q

What is cryoprecipitate reduced? What does this treat?

A
  1. leftover plasma in cryoprecipitate
  2. used for treating Thrombotic thrombocytopenic purpura (TTP)
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18
Q

What is plasma 24?

A

plasma thawed within 24 hrs

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19
Q

Is plasma thawed past 5 days still theraputic?

A

yes, it just has less factor V and factor VIII

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20
Q

What deficiency is NOT treated with plasma?

A

Congenital Coagulation Factor Deficiency
(NEED A LOT or would cause volume overload if you used enough to be therapeutic)

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21
Q

What is a coagulation factor unit?

A

the (1 unit of coagulation factor) activity in 1 mL of pooled normal plasma; 1unit/mL or 100 units/dL

22
Q

How is cryoprecipitate made?

A

precipitates form when frozen plasma is slowly thawed at 1-6C

23
Q

What is the difference between Fresh Frozen Plasma (FFP) and cryoprecipitate, in terms of coagulation factors?

A
  1. Fresh Frozen Plasma (FFP) = all coag. factors
  2. cryoprecipitate = fibrinogen, factor VIII, factor XIII, and large von Willebrand factor (VWF)
24
Q

What is the difference between Fresh Frozen Plasma (FFP) and cryoprecipitate, in terms of volume?

A
  1. Fresh Frozen Plasma (FFP) = large volume
  2. cryoprecipitate = smaller volume
25
Q

How much fibrinogen should be in each unit of cryoprecipitate?

A

at least 150mg of fibrinogen

26
Q

What can be used as a fibrin sealent?

A

cryoprecipitate

27
Q

How many units of factor VIII should be in each unit of cryoprecipitate?

A

80 units of factor VIII

28
Q

How are derivatives different from blood components?

A

prepared by further manufacture of pooled, human source plasma, as well as from recombinant DNA technology

(??? idk i think it just means further filtered to have an abundance of one specific factor???)

29
Q

How are plasma-derived derivatives treated to destroy viruses in the unit?

A
  1. heat
  2. solvent detergent process
30
Q

What does the solvent detergent process destroy (for virus-free derivatives)?

A
  1. HIV
  2. HBV
  3. HCV
31
Q

How are Activated Factor VII (VIIa) Derivatives produced?

A

recombinant DNA technology

32
Q

What are Activated Factor VII (VIIa) Derivatives approved for (and not approved lol)?

A
  1. Hemophilia w/ inhibition of Factor VIII or IX
  2. congenital Factor VII deficiency with bleeding or prior to surgery (treatment)
  3. Glanzmann’s thrombasthenia w/ absence or decreased response to platelet transfusions
  4. (off-label/ NOT APPROVED) uncontrolled bleeding during surgery or from trauma
33
Q

Factor VIII Concentrate Derivatives:
1. derived from…
2. treatment for…

A
  1. Plasma derived
  2. for treatment of hemophilia
34
Q

What is Humate-P? What is it used for?

A
  1. Factor VIII concentrate containing vWF
  2. treatment of vWD

hUMate-P = vWF (m = W) (P=F)
humATE-p = factor VIII

35
Q

What is Recombinant Factor VIII Derivatives used for?

A

prevent and treat bleeds in patients with hemophilia A

36
Q

What is used to replace Factor VIII Concentrate Derivatives?

A

Recombinant Factor VIII Derivatives

37
Q

What is used to replace Porcine Factor VIII Derivatives?

A

recombinant VIIa

38
Q

What is Porcine Factor VIII Derivatives used for?

A

hemophiliacs with (factor VIII) inhibitors
(people who bleed a lot b/c they do not have normal clotting factors)

39
Q

Where is factor IX derivatives, derived from?

A

both plasma derived and recombinant formulation

40
Q

Where is factor XIII derivatives, derived from?

A

recombinant-derived

41
Q

What is fibrinogen derivatives?

A

plasma-derived

42
Q

What is Fibrinogen derivatives used for?

A

congenital afibrinogenemia treatment

43
Q

Where is Immune Serum Globulin Derivatives derived from?

A
  1. Intravenous (IV)
  2. Intramuscular (IM) formulations
44
Q

What diseases use Immune Serum Globulin Derivatives as treatment?

A
  1. Wiskott-Aldrich syndrome
  2. SCIDs ( Severe Combined Immunodeficiency Disease)
  3. Immune thrombocytopenia (ITP)

Globulin = Old people = Wiskott
Wiskott got SCID marks In TP

45
Q

What types of albumin derivatives are available?

A
  1. 5%
  2. 25 %
46
Q

What diseases/situations do you use albumin derivatives?

A
  1. (liver disease) patients who are hypovolemic and hypoproteinemic
  2. patients in shock
  3. burn patients
47
Q

What is Anti-Thrombotic Derivatives?

A

Anti-thrombin (AT) and protein C concentrates

48
Q

Who would need Anti-Thrombotic Derivatives?

A

patients deficient in Anti-thrombin (AT) and/or protein C

49
Q

What derivatives come from only Recombinant DNA technology?

A
  1. Activated Factor VII (VIIa)
  2. Recombinant Factor VIII
  3. Factor XIII
50
Q

What derivatives come from only plasma?

A
  1. Factor VIII Concentrate
  2. fibrinogen

BMS 185 Lecture (11 decks)

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