Lecture 2 Flashcards Preview

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Flashcards in Lecture 2 Deck (10)
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1

what are the phases of mitosis and what happens in each

prophase - condensation of sister chromatids
metaphase - attachment of mitotic spindle to kinetochore
anaphase - seperation of sister chromatids to each pole
telophase - nuclear envelope reassembly

2

what is is called when we use Xenopus oocytes to study mitosis

cell free mitosis

3

what cyclin drives entry into mitosis

M-Cdk
causes assembly of spindle
chromosome condensation
breakdown of nuclear envolope
rearrangement of cytoskeleton and Golgi
levels increase through G2 and M

4

what are the 2 targets of anaphase promoting complex i.e. ubiquitin ligase

1. securin - holds sister chromatids together
2. S and M cyclins

5

what is it called when you lose an allele

heteropzygosity

6

what are the three types of mitotic spindle

interpolar spindle - overlap
kinetochore spindle - attach chromosomes
astral - position spindle

7

how are inappropriate attachments of spindle sensed

tension
correct = pulled in opposite direction
incorrect = lower tension that causes inhibitory signals

8

what activates APC

Cdc20

9

how do you lode homozygosity in mitosis

nondisjunction
gene conversion

10

describe gene conversion

DNA polymerase jumps between strands