Lecture 2: Intro To Immunology Flashcards
(75 cards)
What cell type secrete TNF?
Macrophages and T cells
What effect does TNF have?
Activation of endothelial cells and neutrophils
Fever
Synthesis of APPs
What cell types secrete IL-1?
Macrophages and endothelial cells
What effect does IL-1 have?
Activation of endothelial cells
Fever
Synthesis of APPs
What cell types secrete chemokines?
Macrophages
Endothelial cells
T lymphocytes
Platelets
What effect does IL-12 have?
IFN-gamma synthesis in NK and T cells
Th1 cell differentiation
What effect do chemokines have?
Chemotaxis and activation of leukocytes
What cell types secrete IFN-gamma?
NK cells
T lymphocytes
What effect does IFN-gamma have?
Activation of macrophages
The only cytokine that macrophages dont secrete
What cell types secrete type I IFN’s (IFN-alpha and beta)?
IFN-alpha = macrophages
IFN-beta = fibroblasts
What effect do type I IFN’s (IFN-alpha, beta) have?
Increased class I MHC expression inn all cells
NK cell activation
What cell types secrete IL-10?
Macrophages and T cells (Th2)
What effect does IL-10 have?
Inhibition of IL-12 production and reduced expression of costimulators and class II MHC molecules
What cell types secrete IL-6?
Macrophages, endothelial cells and T cells
What effect does IL-6 have?
Synthesis of APPs!
Proliferation of B cells
What cell types secrete IL-15?
Macrophages
What effect does IL-15 have?
Proliferation of NK cells and T cells
What cell types secrete IL-18?
Macrophages
What effect does IL-18 have?
IFN-gamma synthesis by NK cells and T cells
How many hours does the innate immune response dominate?
0-12 hours
How many days does it take for Ab secretion after a primary infection?
5-7
How many days does it take for Ab secretion to occur after a secondary infection?
3-4 days
How many hours after a primary infection does it take for induced innate/broadly specific response to occur?
4-96 hours
- Phagocytosis, complement activation, cytokine secretion
How many hours after a primary infection does does t take for an induced adaptive/highly specific response to occur?
> 96 hours
- B cells, helper T cells and CTLs