Lecture 3 Flashcards
(25 cards)
What is Ras
small Gtpase
What activate Ras
GTP
What does Ras do
MAPK amplification
Cell division
Faster cell proliferation
What are the types of Ras 3
KRAS , NRAS , HRAS
What re the domain of Grb2 and bind to what
One SH2 phospho-tyrosine
Two SH3 Sos
What makes RAS cause cancer
Strong bond with GTP
absent or slow GTP break down
what does PIK3 do
Convert PIP2 to PIP3
PIK3 has two subunit mention them
Regulatory subunit p85
Catalytic subunit p110
What activated PIPK3
KRAS
Which substance opposite of PIK3
PTEN
PIP3 activates ?
Akt
Akt activate and inhibit what
Activate : mTOR , Glut4
Inhibit Foxo , bim, bad , GSK3
When Akt activate mTOR what promote
Cell growth , metabolism
When Akt activate Glut4 what promote
Glucose uptake
When Akt inhibit GSK3 what promote
Glycogen metabolism and cell cycle progression
Bad , Bim , Bax are
Pro-apoptotic
When Akt inhibit Bim , Bax , Bad what promote
Cell survival
Why does Akt inhibit FoxO
Because FoxO promote Bim production
NO regulate what
Guanylate cyclase
What are NO functions
Smooth muscle relaxation
Neurotransmitter
Reduce blood pressure
Platelet aggregation
What produce NO
Nitric oxide synthase ( NOS )
Where does NO produce
Neuronal cell , endothelial cell , macrophages
Production of No is controlled by
Cytokines and bacterial endotoxins
What do cytokines and bacterial endotoxins do
Regulate ca to produce No ( nNOS , eNOS )
Regulate NOS in gene level
