lecture 35 Flashcards
(8 cards)
1
Q
what are T cells?
A
- lymphocytes that arise in the bone marrow and fully develop in thymus
- Recognise MHC / peptide complexes
2
Q
how does Thymic gene rearrangement work?
A
- Immature T cells rearrange the ‘variable’ parts of their TCR genes in the thymus
- rearrangement process is essentially random
- individual T cells are
unique in terms of their TCR, creates diversity
3
Q
what are naive t cells?
A
T cells that have not been activated by MHC / peptide
4
Q
what are effector t cells?
A
activated t cells
5
Q
what do CD4 helper T cells do?
A
- Recognises MHC-II / peptide
- makes antibody
- Helps CD8 T cell become cytotoxic
6
Q
what do CD8 T cells do?
A
- Recognise MHC-I / peptide
- develops into cytotoxic T cell
7
Q
what do cytokines do?
A
help activate CD8
8
Q
what are memory T cells?
A
- from T cell activation
- reside in body for long periods of time
- become effector cells quicker than naive cells
