lecture 4 Flashcards
vancomycin spectrum
gram positive aerobes
does vancomycin have gram negative activity?
no, too large to cross outer membrane
what is second line for C. diff?
vanco
mechanism of vanco?
inhibits glycoprotein cell wall synthesis.
vance: static/cidal
T dep or C dep?
cidal, TD
PK or vanco
poorly absorbed ( use PO for c.diff). monitor trough levels
mechanism of macrolides
reversibly binds 50s ribosomal subunit
spectrum of macrolides
gram positive, narrow gram negative and atypicals
is macrocodes static/cidal
static
elimination of azithromycin through what?
bile, minimal renal excretion
should be worried about what with azithromycin
drug interactions, CYP3A4 inhibitor
mechanism of clindamycin?
binds to 50S ribosomal subunit
spectrum of clinda?
gram positive aerobes broad and anaerobes broad
is clindamycin time dep or concentration dep?
time
PK or clindamycin
good oral absorption, liver metabolism, excreted in bile and urine
AE of clinda
metallic taste and C.diff
mechanism of aminoglycosides
irreversibly binds 30s ribosomal subunit causing misreading
aminoglycosides:
static/cidal
Conc dep or time dep?
cidal, concentration
ahminoglycosides requires routine what?
monitoring of serum levels for efficacy and toxicity
spectrum of aminoglycosides
synergy with gram positive organisms, broad gram negative activtiy
which antibiotic distributes only into extracellular space?
ahminoglycosides
mechanism of tetracylines
Reversibly binds 30S ribosomal subunit,
tetracycline:
cidal/static
time dep or conc cep
static, time
what can be used for lyme disease?
tetracycline
