Lecture 5 - Gastrointestinal Disease 1 Flashcards Preview

MIIM20002 - Microbes, Infections, Responses > Lecture 5 - Gastrointestinal Disease 1 > Flashcards

Flashcards in Lecture 5 - Gastrointestinal Disease 1 Deck (26):
1

What are the typical symptoms of gastrointestinal disease?

Vomiting
Diarrhoea
Fever
Abdominal pain

2

What is the difference between diarrhoea and dysentery?

Diarrhoea: no blood
Dysentery: blood, due to inflammation

3

Why will gastrointestinal disease cause death?

Due to fluid loss

4

What is the difference in prognosis of gastrointestinal disease in different parts of the world?

Developed world:
- self-limiting
- not life threatening

Non-developed world:
- can be life threatening
- leads to malnutrition, growth retardation

5

What is the definiation of a reservoir?

A living thing in which an infectious agent normally lives and multiplies

6

What are the main sources of infection for gastrointestinal disease?

Faeces
Fingers
Food
Fluids
Fornication

7

Discribe how the faecal-oral route may lead to infection?

Human / animal faeces contaminates food / water

8

Can people who aren't presenting with symptoms of the disease be excreting the pathogen?

Yes

9

Which bacteria to poultry excrete?

Campylobacter
Salmonella

10

Which bacteria to cattle excrete?

Salmonella
E. coli

11

Which bacteria do pigs excrete?

Yersinia

12

How can we thwart faecal contamination of food?

Proper cooking techniques

13

Give some examples of how contaminated fluids can cause disease

Cholera: drinking contaminated water

Vibrio parahaemolyticus: oysters take in the bacteria

Giardia: swimming in contaminated water

14

How do 'fingers' play a role in disease?

They can convey microbes into the mouth

15

How may the habits of the food handler affect disease?

Normal flora from the handler can cause disease

16

What are fomites?

Inanimate objects with bacteria on them

17

What are the features of intoxication?

- Quick onset
- Not neutralised by cooking --> heat stable
- Mainly vomiting

18

What factors affect the likelyhood of bacteria surviving the GIT to cause disease?

- Use of antacids
- Dysbiosis
- Protection with food; chocolate, cheese

19

Which infections cause dysentery?

Shigella
Entamoeba histolytica

20

Which viruses cause watery diarhoea?

Cholera
Rotavirus
ETEC

21

If there is inflammation of the GIT, there will be...

Bloody diarrhoea

22

What is classed as long and short incubation period?

Short: 2-6 hours

Long: 12-48+ hours

23

Which pathogens have a low infectious dose? Why?

Shigella, it is acid stable

24

Which pathogens have a high infectious dose?

ETEC

25

Which specimens are used for investigation of gastrointestinal disease?

Faeces
Food
(Vomit)

26

Which lab procedures are used to investigate infections?

1/ Microscopy
- light, electron

2/ Latex agglutination, EIA (enzyme immuno assay)

3/ PCR, gel electrophoresis