CD4+ T Cell Differentiation Pathways Flashcards Preview

MIIM20002 - Microbes, Infections, Responses > CD4+ T Cell Differentiation Pathways > Flashcards

Flashcards in CD4+ T Cell Differentiation Pathways Deck (13):
1

When is TGF-beta released as Signal 3?

• When self antigen is presented in MHC (ie no pathogen)

or

• Early in infection

2

What does TGF-beta stimulate?

Treg

3

Which cytokines does Treg release?

• IL-10
• TGF-beta

4

When is IL-6 released?

• Early in infection

5

What does IL-6 + TGF-beta stimulate?

Th17
(neutrophil recruitment)

6

Which cytokines does Th1 release?

• IL-6
• IL-17

7

Which cytokines are released if infection persists?

IL-12

8

What does IL-12 stimulate?

Th1
• macrophage activation
• Antibody, IgG

9

Which cytokines does Th1 release?

• IFN-gamma
• TNF

10

What does IL-4 + IL-33 result in?

Th2
• Mast cells
• Eosinophils
• IgE
(allergy, parasite immunity)

11

Which cytokines does Th2 release?

• IL-4
• IL-5

12

What does IL-6 stimulate?

• Tfh
(B cell help)

• Th17
(neutrophils)

13

Which cytokines does Tfh release?

IL-21