Lecture 5 Part 2 Flashcards
(13 cards)
Myelodysplasia
Occurs due to irreversible stem cell injury like FeLV
Abnormal cell production associated with 1 or more cytpopenias and abnormal morphology
Most common in cats than dogs
Animals may die soon after diagnosis with or without progression to neoplasia
Neoplasia
Uncontrolled growth of cells of marrow or lymphoid origin
Uncontrolled growth of cells of marrow origin
Myeloproliferative disease
Myeloid leukemia
Excludes lymphocytes
Further classified by what type of cell is being targeted
Uncontrolled growth of cells of lymphoid origin
Lymphoproliferative disease
May develop from B, T, or NK cells
3 categories- lymphocytic leukemia, lymphoma, multiple myeloma
Leukemia
Neoplasia of blood cells
Starts in bone marrow and circulates into blood
Acute leukemia
Leukemia of immature (blastic) cells
Rapidly progressive
Worse prognosis
Chronic leukemia
Leukemia of mature cells
Slow progression
Better prognosis
May transform into blast crisis
Myeloid leukemia
Leukemia of nonlymphoid origin
Rapidly progressive
Worse prognosis
Lymphoid leukemia
Leukemia of lymphocytes
Slow progression
Better prognosis
Lymphoma
Very common in dogs/cats
Cause often not known
Start as solid tumor and spreads
Can cause hypercalcemia
Diagnosed when more than 50% of the lymphocytes are not small lymphocytes in bone marrow
Multiple myeloma
Neoplasm of plasma cells- uncontrolled growth of ONE clone
Can produce hyperglobulinemia of one protein (monoclonal gammopathy)
Bence jones proteins
When neoplastic lymphocytes only produce light chain of immunoglobulins and they link into urine
Diagnostic criteria of multiple myeloma
Must have at least 2:
Plasma cells in bone marrow
Monoclonal gammopathy
Bence jones proteinuria
Osteolytic lesions
