Lecture 6: Protein Folding Flashcards Preview

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Flashcards in Lecture 6: Protein Folding Deck (5)
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0
Q

Explain the “folding funnel” diagram

A

It shows that as the protein becomes more and more folded, entropy decreases.
This is due to the hydrophobic effect

1
Q

How is folding hierarchical?

A

As a certain number of translated amino acids appear from the ribosome, they fold up…when another group of amino acids appears from the ribosome, they fold up (with the first group), etc…
*This also explains the concept of “repeating motifs”

2
Q

What are the amino acids that destabilize a chain? Why do they destabilize the chain?

A

Gly- has no “r” group which allows greater rotation around psi and phi
Asn, Ser, Asp- have “r” groups that interact with the main chain (backbone)
Pro- has “r” group that is part of the main chain (causes kinks in alpha-helices)

3
Q

Can proteins undergo metamophosis?

A

Yes

4
Q

Explain the concept of “content dependent” in regards to protein folding

A

The same sequence of amino acids can take on different shapes in different proteins