LECTURE 66 & 67 - constipation / IBS Flashcards

(66 cards)

1
Q

List common causes of constipation

A
  • Dietary:
    — Poor fluid intake
    — Decreased calorie intake
  • Failure to heed defecation reflex
  • Impaired physical mobility
  • Lack of privacy (LTCF)
  • Increased physiological distress
  • Disease states that slow down GI motility
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2
Q

List disease states that slow down GI motility

A

Diabetes
Parkinson’s
CNS injury or disease
MS

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3
Q

List medications that could cause constipation

A
  • Analgesics (opioids, NSAIDs)
  • Antacids
  • Agents with strong anticholinergic properties
    (antihistamines, antimuscarinics, amitriptyline)
  • Verapamil, Clonidine, Ca Channel blockers
  • Iron preparations
  • Diuretics
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4
Q

What is considered a normal GI transit time?

A

30-40 hours
up to 72 hours

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5
Q

Describe the effect that slow GI transit time has on the movement of water in/out of stool

A
  • Slow transit results in more time for colon to absorb water from waste
  • Resulting in stool becoming hard & difficult to push out
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6
Q

Define constipation

A

Disorder of colonic motility and/or anorectal function

Usually involves both decreased frequency plus signs & symptoms

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7
Q

List common symptoms of constipation

A

Cramping
Bloating
Lumpy/hard dry stools
Straining
Sensation of incomplete evacuation or blockage

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8
Q

List the key features of acute constipation

A
  • Stools are dry & hard
  • Bowel movements (BMs) are painful & stools difficult to pass
  • Feeling that bowels have not been fully emptied
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9
Q

Describe causes of acute constipation

A

Usually brought on by change in condition or drug

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10
Q

Define acute constipation

A

A noticeable change in normal bowel movement pattern

Less than 3 bowel movements / week

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11
Q

Define chronic constipation

A
  • Symptoms lasting > 6 weeks
  • May respond to laxatives, but returns when d/c meds
  • Does not respond to dietary changes alone
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12
Q

List primary causes of chronic constipation

A
  • Normal transit “functional” + symptomatic
  • Slow transit
  • Evacuation disorder
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13
Q

List secondary causes of chronic constipation

A
  • Medications
  • Obstruction (cancer, stricture)
  • Metabolic (hypothyroid, hypercalcemia)
  • Neurological (parkinsonism, MS)
  • Systemic (scleroderma, amyloidosis)
  • Psychiatric (depression, eating disorders)
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14
Q

List the Rome III criteria for functional constipation

A

2+ of the following:

Straining
Lumpy / hard stools
Sensation of incomplete evacuation
Sensation of anorectal obstruction / blockage
Manual maneuvers to facilitate defecations
< 3 defecations per week

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15
Q

What types of medications are used for GI procedure prep?

A

Hyperosmotics or saline laxatives

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16
Q

What type of diet should patients start the day prior to a GI procedure?

A

Clear liquid diet
ex) jello, broth, popsicles, gatorade, clear juices, coffee

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17
Q

When should patients begin GI procedure prep (generally)?

A

afternoon / evening prior to procedure

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18
Q

What is KEY to prepping correctly for a GI procedure?

A

Drinking large quantities of fluids

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19
Q

Describe correct dosing of Polyethylene Glycol for oral prep for GI procedures

A

2-4 L
8 oz q10 minutes
refrigerate

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20
Q

Describe the procedure for SAS prep

A

day before procedure
1. enjoy clear liquids all day
2. mix 1 bottle of MiraLAX into 2 bottles of gatorade (refrigerate)
3. drink an extra 8 oz of clear fluid every hour while awake
4. take 4, 5mg bisacodyl tabs at 12pm (noon)
5. at 2pm, drink 1st bottle of MiraLAX/gatorade solution over 1 hour (8oz q10-20 minutes)
6. wait 30 minutes
7. drink 2nd bottle at the same rate

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21
Q

Describe habits that promote regular bowel habits

A
  • include ample fluids & fiber in diet
  • PRUNES !!!
  • Do NOT ignore the urge to defecate
  • Establish a regular, unhurried time for bowel movements
  • Encourage pts to defecate when colonic activity is greatest
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22
Q

Explain how patients can ensure ample fiber in diet / start including more fiber

A

20-30 g fiber/day

Add high-fiber foods to diet SLOWLY
(increase over 7-10 days)

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23
Q

How much fluids should patients consume

A

6-8 glasses of water per day

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24
Q

Give examples of high-fiber foods

A

Vegetables, fruit, beans, whole grains

Fresh green kiwifruit → 2 / day
Dried pitted prunes → 12 g / day
Powder psyllium → 12 g / day

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25
Explain the advantages of adding high-fiber foods to diet slowly
Minimizes gas Natural fiber is degraded by bacteria
26
When is colonic activity the greatest?
- First thing in the AM - Within 30 minutes after meals
27
Explain the appropriate treatment for pts within constipation on opioids (OIC)
Stimulants (bisacodyl, senna) THEN, add docusate, lactulose, or PEG PRN **Avoid bulk laxatives**
28
Explain the next steps for treatment of OIC if other treatments have not been sucessful
Opioid receptor antagonists: -- Relistor (methylnaltrexone) -- Movantik (naloxegol)
29
What is the best treatment for acute constipation if the pt desires relief within 1 hour?
- Enema (saline, tap water, soap suds) - Bisacodyl / Glycerin suppository **fleets is the fastest relief**
30
What is the best treatment for acute constipation if the pt desires relief within 3-6 hours?
- Citrate of Magnesia - Larger doses of polyethylene glycol (PEG)
31
What is the best treatment for acute constipation if the pt desires relief within 24 hours?
Bisacodyl or Senna Tablets
32
What is the best treatment for acute constipation if the pt desires relief within 48 hours?
- Milk of Magnesia - PEG (MiraLAX)
33
What is the first step that should be taken to relieve chronic constipation?
Dietary modifications
34
What is the 2nd step that can be taken to relieve chronic constipation?
Bulk forming laxatives & fluids **titrate dose**
35
What is the 3rd step that can be taken to relieve chronic constipation?
PEG (MiraLAX) Lactulose Sorbitol **titrate dose**
36
What is the 4th step that can be taken to relieve chronic constipation?
Short-term use of stimulant THEN maintenance agent
37
What is the final step that can be taken to relieve chronic constipation?
Lubiprostone Linaclotide Prucalopride Plecanatide **Usually reserved for chronic idiopathic constipation**
38
Describe the MOA of bulk laxatives
Forms emollient gels which retain water, swells & stimulates BM
39
List advantages of bulk laxatives
Soften stools better than docusate Well tolerated, few SE
40
List disadvantages of bulk laxatives
Taste **Must have adequate fluid intake** Gas formation Impact on drug absorption Not ideal for bedridden patients
41
List examples of bulk laxatives
Metamucil (psyllium) Citrucel (methylcellulose) Fibercon (calcium polycarbophil)
42
Describe the MOA of surfactant / emollient
Decreases fecal surface tension Stool softener
43
List advantages of surfactant / emollient
Safe Helps prevent hard stools (hemorrhoids)
44
List disadvantages of surfactant / emollient
?? efficacy Not effective for active constipation
45
List examples of surfactant / emollient
Docusate (DOSS) dosing: 100 mg QD/BID
46
Describe the MOA of lubricant
Lubricates lumen of colon
47
List examples of lubricants
Mineral Oil dosing: 30-60 mL QD
48
List advantages of lubricants
Lubricates & softens
49
List disadvantages of lubricants
Poor pt acceptance, oily Only effective in prevention of constipation May decrease absorption of fat-soluble vitamins
50
Describe the MOA of saline laxatives
Draws fluid into colon which stimulates motility
51
List advantages of saline laxatives
Used for acute management of constipation, quick onset Most economical
52
List disadvantages of saline laxatives
Possibly taste Avoid in renal pts (Na, Mg)
53
List examples of saline laxatives
Milk of Magnesia Mg Citrate Fleet’s Saline Enema
54
Describe the MOA of hyperosmotic agents
Draws fluid into colon due to high concentration of sugar, PEG, or glycerin
55
List advantages of hyperosmotic agents
Well tolerated Softens while stimulating BM Excellent for CHRONIC constipation
56
List disadvantages of hyperosmotic agents
1-3 day onset at usual doses Minor nausea, cramping
57
List examples of hyperosmotic agents
Sorbitol Lactulose PEG MiraLAX Glycerin suppositories
58
Describe the MOA of stimulant laxatives
Locally stimulates enteric nerves which stimulates contractions & mobility, also increases fluid & Na secretion into the lumen
59
List advantages of stimulant laxatives
- 6-12 hour onset - Works in pts with motility disorders - **Drug of choice for opioid induced constipation (OIC)**
60
List disadvantages of stimulant laxatives
Risk of nausea & cramping Avoid long-term continuous use in pts with normal GI motility
61
List examples of stimulant laxatives
Senna Bisacodyl Bisacodyl suppositories
62
What is the drug of choice (DOC) for opioid induced constipation (OIC)?
stimulant laxatives (senna)
63
What is the follow-up timeframe for ACUTE constipation?
1-2 days
64
What is the follow-up timeframe for CHRONIC constipation?
1-2 weeks
65
What symptoms should be assessed during a follow-up?
Stool frequency Episodes of diarrhea Dietary changes Any SE from meds
66
What does the acronym "IESA" stand for?
Is the drug INDICATED? Is the drug EFFECTIVE? Is the drug SAFE? Is the drug Convenient / ADHERENCE?