lecture 8 Flashcards
Nathan Augustus Cobb
1894 described wheat strains
enduring fungal infections
true or false: disease tolerance is context dependant
true
what can affect disease tolerance
-genetics
-receptor downregulation
-tissue repair
-gut microbiota
-immune silencing
what is disease tolerance
high pathogen load and high host health
what is resistance
lower pathogen load high host health
true or false: type 1 and type 2 immunity are mutually antagonist
true
type 1:
Intracellular Pathogens
Bacteria
Viruses
-type 2
Allergens
Helminths
Damage
true or false: Type 2 Immunity Drives Host Resistance to hiv Infection
Type 2 Immunity Drives Host Resistance to Hpb Infection
IFNy signaling compromises host resistance to… and what type of immunity is it
hpb
type one
IFNy signaling in the intestinal epithelium promotes Disease Tolerance to
hpb
true or false: inf gamma can cause tissue repair
true
IFNy Drives the Local Recruitment of Neutrophils
Neutrophils Support Tissue Repair
- Type 1 Immunity promotes
- Type 1 Immunity promotes Host Resistance
- Cytotoxic effects on invading pathogens
Type 2 Immunity promotes
Type 2 Immunity promotes Disease tolerance
* Tissue repair
* Epithelial proliferation
true or false: in the context of helminths type 2 immunity promotes host resistance
true
Reprogramming of intestinal epithelial cell barrie
true or false: in the context of helminths type 1 immunity promotes Disease Tolerance
Type 1 Immunity compromises Host Resistance while promoting Disease Tolerance
* IFNg-recruited Neutrophil-induced tissue repair?
