Lecture 8a Flashcards Preview

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Flashcards in Lecture 8a Deck (32):
1

Artificial active immunity

Immunization

2

Natural passive immunity

Maternal Ab to fetus or newborn

3

Artificial passive immunity

Gamma globulin shot

4

Adoptive immunity

Transfer immunocompetent cells (bone marrow)

5

Oral exposure generates

sIgA and sIgM
And some systemic IgG

6

Blood brain barrier can become more permeable during

Inflammation

7

IgG is found at ___% in CNS serum

0.2%

8

Natural active immunity

Recover from infection

9

paneth cells

in base of crypt,
release TGf-beta, IL-1, IL-7, and chemokines

10

_____ can increase expressions of MHC I on astrocytes if neurons are damaged.

IFN-gamma

11

bacterial infections

highly invasive
localized with invasive toxin
localized with local toxicity
septicemia and bacteremia

12

major defenses against bacteria

Ab
phagocytosis
complement cascade
NK and Tc (intracellular pathogens)
TLRs and LPS

13

LPS (lipopolysaccharides) come from

gram-negative bacteria,
can cause an inflammatory response

14

extracellular infection

TH1 and TH17

15

intracellular infection

CD8 Tc

16

major influence in diseases

bacterial exotoxins

17

superantigens

cytotoxic shock

18

bacterial GI infections salmonella

S. typhii (typhoid)
S. typhimurium (food poisoning)
infects mucosal lining at M cells- apoptosis

19

bacterial GI infections clostridium

C. dif
Clostridium difficile
opportunistic
produces toxins that damage mucosa

20

bacterial GI infections shigella

dysentery
Shiga toxin

21

non-enveloped virus replication cycle

1. recognition
2. attachment
3. penetration
4. uncoating
5. transcription
6. protein synthesis
7. replication
8. assembly
9. lysis and release

22

enveloped virus replication cycle

1. recognition
2. attachment
3. fusion
4. replication
5. envelopment
6. budding and release

23

major defenses against viruses

interferon alpha/beta
CD8+Tc is best
NK is good, K if Ab is bound

24

____ cells kill virus-infected cells

CD8

25

antigenic drift

point mutations that occur frequently in viruses

26

antigenic shift

reassortment of RNA segments in cell infected with 2 viruses

27

antigenic sin

body's inability to maximize response due to recognizing an antigen as original version antigen. Only uses antibodies for the original.

28

many viruses inhibit

MHC I

29

HIV infects

CD4 cells

30

Epstein-Barr infects

B cells

31

parasitic infections sometimes have an elevated ___ level

IgE

32

Helminthes GI infections

TH2 response, IgE produced
IL-5 activates eosinophils, which release MBP
IL-3 and IL-9 stimulate mast cells
eosinophils bind larva, IgE binds parasite