Lecture12 : Pain Physiology

Question 1

When is Arachidonic acid released?

Answer 1

During tissue damage

Question 2

When is histamine released?

Answer 2

After tissue damage via mast cells

Question 3

When is Potassium increased?

Answer 3

Following tissue damage

Question 4

Are NSAIDs effective in minimizing pain?

Answer 4

Yes

Question 5

Which fibres have fast pain conduction?

Answer 5

A Delta

Question 6

Which pain fibres are for precise pain localization?

Answer 6

Alpha Delta

Question 7

Which pain fibres are unmyelinated?

Answer 7

C fibres

Question 8

Which pain fibres have slow conduction?

Answer 8

C fibres

Question 9

Which Pain fibres carry information from polymodal nociceptors?

Answer 9

C fibres

Question 10

Which pain type is caused by prick and induces flexion withdrawal?

Answer 10

Nociceptive ( Acute pain)

Question 11

Which fibres are for burning/soreness pain?

Answer 11

C-fibres

Question 12

Which fibres are for sharp pricking pain?

Answer 12

A delta fibres

Question 13

What is the mechanism of prolonged pain?

Answer 13

Development of areas of hypersensitivity around the injury site

Question 14

How long does neuropathic/chronic pain last?

Answer 14

2/3months

Question 15

What does neuropathic/chronic pain present as?

Answer 15

Burning or pins and needles sensation

Question 16

What does neuropathic/chronic pain respond well to?

Answer 16

Antidepressants or anticonvulsants

Question 17

Explain Peripheral sensitization

Answer 17

After a peripheral nerve lesion, neurons become unusually sensitive. Thus heightened sensitivity to stimuli

Question 18

What is hyperalgesia?

Answer 18

When the threshold for pain in site of injury is lowered

Question 19

What is Allodynia?

Answer 19

Pain from stimulus that doesn’t normally produce pain