Lesions of the Vulva, vagina and Other HPV Driven Diseases

Question 1

HPV driven disease?

Answer 1

• Vulvar intraepithelial neoplasia
• Vaginal intraepithelial neoplasia
• Anal intraepithelial neoplasia
• All graded I-III and III is squamous cell carcinoma in situ

Question 2

What is vulvar intraepithelial neoplasia?

Answer 2

Condition characterized by disorientation and loss of epithelial architecture extending through the epithelium

Question 3

Who does vulvar intraepithelial neoplasia occur in?

Answer 3

Young women between 30-50

Assoc with smoking and PHV infection

Question 4

What will patients complain of Vulvar intraepithelial neoplasia?

Answer 4

May be asymptomatic or complain of

• Oruritus
• Pain
• Dysuria
• Ulceration

Question 5

Lesions in vulvar Intraepithelial neoplasia?

Answer 5

White
Pink
Pigmented in the form of plaques or papules

Question 6

What can VIN progress to?

Answer 6

Invasive disease (SSC of the vulva)

Question 7

Acronym for vulvar intraepithelial neoplasia?

Answer 7

VIN

Question 8

What is a less common form of VIN?

Answer 8

Differentiated Vulvar Intraepithelial Neoplasia (dVIN)

Question 9

What is dVIN?

Answer 9

Less common form of VIN, not related to HPV but still precursor of SSC

Question 10

What is the often a background of in dVIN?

Answer 10

Inflammatory dermatoses such as lichen sclerosis

Question 11

How common is vulvar invasive SCC and who does it often occur in?

Answer 11

Older women

Rare

Question 12

Important prognostic factor in Vulvar Invasive SCC?

Answer 12

Whether cancer has spread to inguinal lymph nodes or not

Question 13

Possible treatment of VIN?

Answer 13

Surgical excision
Laser ablation
Cryosurgery

Question 14

Primary tumours of vagina, common or rare?

Answer 14

Rare

-disease of the elderly