Leukemia Flashcards
(23 cards)
What is the most common cause of generalized lymphadenopathy in patients > 65 years?
Chronic lymphocytic leukemia (CLL)
What cancer may be associated with IgM-mediated immune hemolytic anemia?
Chronic lymphocytic leukemia (CLL)
Which leukemia is associated with smudge cells on blood smear?
Chronic lymphocytic leukemia
Chronic myelogenous leukemia (CML) is distinguished from a leukemoid reaction (benign neutrophilia) by a:
Negative leukocyte alkaline phosphatase (LAP) stain
What is the likely diagnosis in a patient with night sweats, weight loss, and splenomegaly? Laboratory exam reveals leukocytosis with increased levels of basophils and myelocytes.
Chronic myeloid leukemia
The t(9;22) translocation (BCR-ABL) is also known as the Philadelphia chromosome most commonly seen in:
Chronic myeloid leukemia (CML)
The painless, generalized lymphadenopathy, splenomegaly and leukocytosis in this older patient (> 65 years) is highly suggestive of:
Chronic lymphocytic leukemia (CLL),
Auer rods (myeloperoxidase inclusions) are suggestive of
AML (esp. APL)
The _____ hematopoietic stem cell may differentiate into a(n) myeloid or lymphoid stem cell
CD34+
Acute promyelocytic leukemia is treated with :
All-trans-retinoic acid (ATRA), a vitamin A derivative, as well as arsenic trioxide
_____ often presents with symptoms related to anemia (fatigue, weakness) and thrombocytopenia (bleeding, petechiae)
AML
- B-ALL with_____has a(n) good prognosis and is more commonly seen in children
- B-ALL with ____ has a(n) poor prognosis and is more commonly seen in adults
- t(12;21)
- t(9;22)
What is the likely diagnosis in a child with bone pain, Bruising, petechiae, bleeding,non-tender lymphadenopathy, and pancytopenia?
Acute lymphoblastic leukemia
Which form of acute leukemia is associated with CALLA and TdT proteins?
B-ALL
Flow cytometry markers of CLL
B cells with CD5 and CD23
Signs of _____ indicate a poor prognosis in chronic lymphocytic leukemia
Decreased bone marrow activity
Treatment CD20 (+) symptomatic CLL =
Rituximab
One subtype of AML is acute promyelocytic leukemia (APL), which is characterized by this translocation:
t(15;17)
Does hairy cell leukemia typically present with lymphadenopathy?
No
The cells in ________stain positive for tartrate-resistant acid phosphatase (TRAP)
hairy cell leukemia
Which chemotherapeutic drug is used to treat hairy cell leukemia?
Cladribine
Which chemotherapeutic drug is used to treat chronic myelogenous leukemia- chronic phase?
Imatinib
Which chemotherapeutic drug is used to treat chronic myelogenous leukemia- blast crisis?
Dasatinib
