Lymphoma

Question 1

Lymphoma diagnosis =

Answer 1

excisional node biopsy

Question 2

Painless lymphadenopathy, B symptoms, and pruritus are seen in:

Answer 2

Hodgkin lymphoma

Question 3

• Hodgkin lymphoma is managed with ______
• Non-Hodgkin lymphoma is managed with _____

Answer 3

• ABVD chemotherapy ± radiation
• R-CHOP therapy

Question 4

The hypercalcemia seen in patients with lymphoma and sarcoidosis is mediated by

Answer 4

calcitriol

Question 5

What is the most common cause of death in multiple myeloma?

Answer 5

Infection

Question 6

What is the likely diagnosis in a patient with anemia, painful osteolytic lesions, hypercalcemia, and recurrent infections?

Answer 6

Multiple myeloma

Question 7

Besides bone marrow biopsy, what is the next step in diagnosis of a suspected plasma-cell dyscrasia?

Answer 7

Whole-body CT scan

Question 8

______ is an asymptomatic condition characterized by an M spike on SPEP without other features of multiple myeloma

Answer 8

Monoclonal gammopathy of undetermined significance (MGUS)

Question 9

The signs/symptoms of multiple myeloma may be remembered with the mnemonic “CRAB”:

Answer 9

• hyperCalcemia
• Renal insufficiency(free light chain (Bence Jones protein) may deposit )
• Anemia
• Bone lytic lesions / Back pain

Question 10

The initial workup of paraproteinemia consists of:

Answer 10

• CBC
• Serum creatinine and calcium measurement
• Immunofixation electrophoresis of serum protein (SPEP)
• Urine protein (UPEP), and SFLC studies

Question 11

The M spike seen in Waldenstrom macroglobulinemia is due to:

Answer 11

monoclonal IgM

Question 12

Does Waldenstrom macroglobulinemia present with lytic bone lesions?

Answer 12

No

Question 13

Waldenstrom macroglobulinemia is associated with symptoms of _______(due to large size of IgM pentamer)

Answer 13

hyperviscosity syndrome
(e.g., vision and hearing loss, headaches, Raynaud phenomenon)

Question 14

he combination of restrictive cardiomyopathy and macroglossia suggests:

Answer 14

AL amyloidosis.

Question 15

Reed-Sternberg cells((“owl eye” appearance)) are classically positive for ____ and are characteristic of ______

Answer 15

CD15 and CD30
Hodgkin lymphoma

Question 16

What is the recommended empiric treatment for high-risk patients with febrile neutropenia?

Answer 16

Broad-spectrum anti-pseudomonal agents (e.g. cefepime, meropenem, piperacillin-tazobactam)