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SS- Heme > Leukemia/Lymphoma drugs > Flashcards

Leukemia/Lymphoma drugs Flashcards

1
Q

AML induction

A

daunorubicin (top II intercalation), cytarabine (ARA-C: antimetabolite) and can add thioguanine (antimetabolite)

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2
Q

post remission: AML

A

ARA-C

autologous bone marrow transplant

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3
Q

APL induction

A

ATRA

arsenic trioxide

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4
Q

Childhood APL induction

A

ATRA, arsenic

anthracycline +/- cytarabine

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5
Q

APL maintenance

A

ATRA, 6-MP and methotrexate

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6
Q

BBW: arsenic trioxide

A

CV problems: AV block, QT prolongation

leukocytosis, APL differentiation syndrome

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7
Q

ALL induction

A

prednisone, vincristine, anthrcycline

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8
Q

ALL: Ph1 positive

A

imatinib +/- chemo

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9
Q

ALL: CNS prophylaxis

A

IT methotrexate

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10
Q

ALL: consolidation

A

methotrexate and mercaptopurine

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11
Q

-nib

A

bind ATP binding site (important for resistance)

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12
Q

CML

A

imatinib is first line

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13
Q

CML list of drugs

A

busulfan, cyclophosphomide, cytarabine, mechlorethamine, hydroxyurea
IFN-2a
nilotinib, dasatinib, imatinib

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14
Q

ALL list of drugs

A

corticosteroid
daunorubicin, daunorubicin
mercaptopurine, methotrexate
vincristine

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15
Q

CLL

A

fludarabine, rituximab, cyclophosphamide

EPO: for the anemia from treatment

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16
Q

Hodgkin lymphoma

A

mitotic spindle inhibitor, anthracycline, DHFR inhibitor (or topo inhibitor), corticosteroid
combinations of these

17
Q

Non-Hodgkin lymphoma

A

rituximab (look at slide)
cyclophosphomide, doxirubicin, vincristine, prednisone
R-CHOP

18
Q

tositumomab

A

radionucleotide anti CD20 Ab

19
Q

ibritumomab

A

radionucleotide anti CD20 Ab

20
Q

BBW: pegaspargase

A

Erwinia hypersensitivity

21
Q

BBW: ATRA

A

APL differenetiation syndrome, leukocytosis

22
Q

BBW: bleomycin

A

lung fibrosis

23
Q

BBW: Busulfan

A

bone marrow suppression, secondary malignancy

24
Q

BBW: carboplatin

A

anemia, infection, kidney

25
Q

BBW: chloarambucil

A

bone marrow suppression, secondary malignancy, pregnancy, infertitlity

26
Q

BBW: anthracyclines (daunorubicin, doxirubicin, idarubicin)

A

heart, extravasional necrosis

27
Q

BBW: hydroxyurea

A

secondary malignancies

28
Q

BBW: IFN alpha-2b

A

CI: autoimmune, cardiac disease

suicide, depression

29
Q

BBW: mechlorethamine

A

pregnancy

30
Q

BBW: vincas

A

peripheral neuropathy (pins and needles)

31
Q

BBW: ozogamicin

A

BM, hepatic, pulmonary, infusion rxn

32
Q

BBW: nilotinib

A

CI: hypokalemia and hypomagnesemia

QT prolong

33
Q

BBW: ibritumomab, tiuxetan

A

exfoliate dermatitis, infusion rxn

34
Q

BBW: tositumomab

A

iodine hypersensitivity, thrombocytopenia, neutropenia

35
Q

BBW: rituximab

A

exfoliate dermatitis, infustion rxn, progressive multifocal leukoencephalopathy

36
Q

BBW: doxirubicin

A

cumulative dose

cardiac

SS- Heme (13 decks)

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