Leukocyte Neoplasms

Question 1

increase in WBC’s in blood
malignant proliferation of WBCs

Answer 1

leukemia

Question 2

increase in the number of myeloblasts in the blood

Answer 2

acute myeloid leukemia

Question 3

increase in the number of granulocytes in the blood

Answer 3

chronic myeloid leukemia

Question 4

increase in the number of lymphoblasts in the blood

Answer 4

acute lymphoblastic leukemia

Question 5

increase in the number of B cells (rarely T cells) in the blood

Answer 5

chronic lymphocytic leukemia

Question 6

disease of children
fever, fatigue, BONE PAIN
hepatosplenomegaly, lymphadenopathy

Answer 6

Acute lymphoblastic leukemia (ALL)

Question 7

peripheral blood

Answer 7

lymphoblasts (ALL)

Question 8

Tdt+

Answer 8

pre B cell or pre T cell

Question 9

lymphocyte antigens

Answer 9

primarily T cell

Question 10

lymphocyte antigens

Answer 10

primarily B cell

Question 11

usually pre B cell malignancy
CD10+
TdT+

Answer 11

ALL

Question 12

2 main translocations in ALL

Answer 12

philadelphia t(9:22)
t(12,21)

Question 13

seen in teens-20s
mediastinal mass
tumor compression can occur (SVCS syndrome)
CD7+

Answer 13

T cell acute lymphoblastic leukemia

Question 14

malignancy of myeloblasts
adult males
bone marrow suppression sx’s

Answer 14

Acute myelogenous leukemia (AML)

Question 15

Answer 15

Auer rods seen in AML

Question 16

contain MPO and Auer rods
if MPO spills out into blood, can lead to DIC

Answer 16

myeloblasts in Acute Myelogenous Leukemia

Question 17

t(15;17) translocation
abnormal retinoic acid receptor
DIC

Answer 17

Acute promyelocytic leukemia (APML)

Question 18

abnormal dysplastic progenitor cells; ineffective hematopoiesis
blasts <20% in blood

Answer 18

myelodysplastic syndrome (MDS)

Question 19

> 20% blasts in blood

Answer 19

acute myelogenous leukemia (AML)

Question 20

malignant disorder of myeloid progenitor cells

Answer 20

chronic myelogenous leukemia

Question 21

dysregulated production of granulocytes

Answer 21

chronic myelogenous leukemia

Question 22

classified as myeloproliferative disorder b/c of the over proliferaiton of cells from the myeloid lineage

Answer 22

chronic myelogenous leukemia

Question 23

neutrophils, eosinophils, basophils

Answer 23

granulocytes

Question 24

median WBC 100,000/microL
leukocytosis
low LAP

Answer 24

chronic myelogenous leukemia

Question 25

normal response to infection more bands and neutrophils WBC 17,000 high LAP

Answer 25

leukemoid reaction

Question 26

translocation hallmark for CML

Answer 26

philadelphia t(9;22) BCR-ABL fusion gene

Question 27

what protein is increased due to philadelphia chromosome in CML (this allows cells to avoid apoptosis)

Answer 27

tyrosine kinase

Question 28

_____ inhibitors used to treat CML

Answer 28

tyrosine kinase -tinibs

Question 29

disorder of naiive lymphocytes (NOT blasts)

Answer 29

chronic lymphocytic leukemia (CLL)

Question 30

CD5+ and CD20

Answer 30

chronic lymphocytic leukemia

Question 31

disorder of naiive lymphocytes lymphocyte count <5000

Answer 31

small lymphocytic lymphoma (SLL)

Question 32

disorder of naiive lymphocytes lymphocyte count >5000

Answer 32

chronic lymphocytic leukemia (CLL)

Question 33

older adults pts often asymptomatic lymphadenopathy, fever, sweats

Answer 33

chronic lymphocytic leukemia

Question 34

smudge cells seen on peripheral blood smear (peripheral lymphocytes are fragile)

Answer 34

chronic lymphocytic leukemia

Question 35

CLL may progress to _____

Answer 35

diffuse large B cell lymphoma

Question 36

pt w/ known CLL rapid growth of single lymph node

Answer 36

diffuse large B cell lymphoma

Question 37

rare chronic B cell malignancy CD20, 21, 103 hair like cytoplasmic projections on lymphocytes on peripheral blood smear

Answer 37

hairy cell leukemia

Question 38

splenomegaly abdominal pain dry tap (these cells induce fibrosis) TRAP staining +

Answer 38

hairy cell leukemia