Limbic System

Question 1

Pathway of the limbic system that projects from hippocampus to mammillary bodies

Answer 1

Fornix

Question 2

Pathway of the limbic system that runs from mammillary bodies to anterior nucleus of thalamus

Answer 2

Mammillothalamic tract

Question 3

Pathway of the limbic system that runs from the amygdala to septal nuclei (in frontal lobe) and hypothalamus

Answer 3

Stria terminalis

Question 4

Pathway of the limbic system that runs from septum and anterior thalamus to habenula (near thalamus)

Answer 4

Stria medullaris

Question 5

Pathway of the limbic system that connects the septum, amygdala, olfactory regions to hypothalamus and brainstem

Answer 5

Medial forebrain bundle

Question 6

Pathway of the limbic system that is deep within the cingulate gyrus and connects wide regions of the cortex

Answer 6

Cingulum

Question 7

This structure of the hippocampal formation has a granule cell layer

Answer 7

Dentate gyrus

Question 8

This structure of the hippocampal formation is a 3 layered cortex with a pyramidal cell layer

Answer 8

Hippocampus

Question 9

Fibers that enter and leave this structure form the fimbria and continue as the fornix

Answer 9

Hippocampus

Question 10

Fibers that enter and leave the hippocampus form this and continue as the fornix

Answer 10

Fimbria

Question 11

Fibers that enter and leave the hippocampus form the fimbria and continue as this

Answer 11

Fornix

Question 12

The amygdala is located anterior to this structure

Answer 12

Hippocampus

Question 13

The amygdala is at the tip of this ventricle

Answer 13

Lateral ventricle

Question 14

This is the most defined output of the amygdala

Answer 14

Stria terminalis

Question 15

This system acts as a “filter” between emotion/drives and rational decision making
Matches the appropriate behavior with satisfaction of a basic drive (hunger)

Answer 15

Limbic system

Question 16

Does the hippocampal formation function in the formation of memories or retention of old memories?

Answer 16

Forming new memories

Question 17

Alzheimer’s disease targets this system initially

Answer 17

Limbic system
(esp. hippocampus and frontal cortex)

Question 18

Microtubule associated protein that is hyperphosphorylated in Alzheimer’s disease and forms neurofibrillary tangles

Answer 18

Tau protein

Question 19

This gene is most commonly mutated in familial Alzheimer’s disease

Answer 19

Presenilin-1

Question 20

Alzheimer’s disease is accompanied by a significant inflammatory response from these cells

Answer 20

Microglia

Question 21

This variant of apolipoprotein E is the strongest genetic risk factor for late onset Alzheimer’s disease

Answer 21

ApoE4

Question 22

Is the ApoE4 gene variant a risk factor for early or late onset Alzheimer’s disease?

Answer 22

Late onset

Question 23

Apolipoprotein E4 is thought to facilitate transport and deposition of this protein

Answer 23

Beta amyloid (Aβ)

Question 24

New data suggests this mutated protein increases the inflammatory response to microglia tau resulting in cell death in Alzheimer’s disease

Answer 24

ApoE4

Question 25

Aducanumab is an antibody that targets this protein

Answer 25

Amyloid beta (used to treat Alzheimer's disease, but very criticized drug)

Question 26

The leading hypothesis of Alzheimer's disease is that accumulation of this is toxic to neurons

Answer 26

Amyloid beta (Aβ)