Property of lipids
Heterogeneous group of compounds, share: 1. Insolubility in water based solutions. 2. Solubility in organic/non-polar solvent.s
Normal saturated fatty acids are generally more soluble in __?
SA FA are generally less soluble in __ ?
5 Biological Functions of Lipids?
Storage of Energy Membrane Structure Signalling Molecules Cofactors for enzymes Antioxidants
Branch 1 Classification of Lipid
Complex and Biologically Active Lipids
Difference between Complex and Biologically Active Lipids
Complex = FA Biologically active = NO FA
Branches of complex lipids (FA)?
Storage and Structural Lipids
Difference between storage and structural lipids?
Storage = non-polar Structural = polar
examples of storage (non-polar) lipids
examples of structural (polar) lipids
Examples of biologically active lipids (No FA)
Define fatty acid
Amphipathic molecules with hydrocarbon chains containing 3 to 35 carbons plus carboxylic group.
pKa of COOH groups?
<5 ... therefore will be fully ionized after this time.
Almost all natural FA have ____
an even # of carbons
FA can be ___
saturated or unsaturated
What are FA physical properties based on?
1) Length of hydrocarbon chain 2) Degree of saturation
All naturally occurring double bonds have __
Most common FA length?
C14 to C18
What is interesting about the 4 carbon FA, or butanoic acid?
-infinitely water soluble -solubility decreases w/ increased hydrocarbon chain length.
Solubility of Lauric acid? (12 carbon FA?)
partially soluble to the extent of 0.06g per gram of water
Fatty acids with C10 or greater form ___ at room temp
Fatty acids with C9 or lower saturates or unsaturated HC chains form ___ at room temperature?
What does the prefix "alpha" indicate?
Normal or unbranched structure. i.e alpha-linolenic acid.
Double bonds in FA chains produce what?
kinks and bends
Due to kinks and bends in unsaturated FA ... this causes what?
1) Unsaturated FA are LESS packed VS saturated 2) LESS ordered packing = WEAKER intermolecular interactions (vanderwall forces) 3) LOWER melting points for unsaturated fatty acids.
Which fatty acids can humans not synthesize? Why do we need them?
LinoLEIC acid, Omega 6. LinoLENIC acid, Omega 3. Need them to synthesize other needed FA, such as AA, DHA, EPA and n-3 and n-6 eicosanoids.
Importance of omega 3?
-inhibit formation of thromboxane A2 (eicosanoids) -> associated with platelet aggregation + clot formation.
Omega 3 FA are associated with decrease risk of what disease?
3 major typed of omega 3 fatty acids?
-alpha linolenic cid (ALA) -EPA -DHA
What are the effective PUFA's?