Lipids/Cell Membrane Flashcards Preview

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Flashcards in Lipids/Cell Membrane Deck (157)
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1

Property of lipids

Heterogeneous group of compounds, share: 1. Insolubility in water based solutions. 2. Solubility in organic/non-polar solvent.s

2

Normal saturated fatty acids are generally more soluble in __?

Chloroform

3

SA FA are generally less soluble in __ ?

Acetonitrile

4

5 Biological Functions of Lipids?

Storage of Energy Membrane Structure Signalling Molecules Cofactors for enzymes Antioxidants

5

Branch 1 Classification of Lipid

Complex and Biologically Active Lipids

6

Difference between Complex and Biologically Active Lipids

Complex = FA Biologically active = NO FA

7

Branches of complex lipids (FA)?

Storage and Structural Lipids

8

Difference between storage and structural lipids?

Storage = non-polar Structural = polar

9

examples of storage (non-polar) lipids

Triglycerides Waxes

10

examples of structural (polar) lipids

Phospholipids Sphingolipids

11

Examples of biologically active lipids (No FA)

Prostaglandins Steroids

12

Define fatty acid

Amphipathic molecules with hydrocarbon chains containing 3 to 35 carbons plus carboxylic group.

13

pKa of COOH groups?

<5 ... therefore will be fully ionized after this time.

14

Almost all natural FA have ____

an even # of carbons

15

FA can be ___

saturated or unsaturated

16

What are FA physical properties based on?

1) Length of hydrocarbon chain 2) Degree of saturation

17

All naturally occurring double bonds have __

CIS configuration

18

Most common FA length?

C14 to C18

19

What is interesting about the 4 carbon FA, or butanoic acid?

-infinitely water soluble -solubility decreases w/ increased hydrocarbon chain length.

20

Solubility of Lauric acid? (12 carbon FA?)

partially soluble to the extent of 0.06g per gram of water

21

Fatty acids with C10 or greater form ___ at room temp

Waxy solids

22

Fatty acids with C9 or lower saturates or unsaturated HC chains form ___ at room temperature?

Oily solids

23

What does the prefix "alpha" indicate?

Normal or unbranched structure. i.e alpha-linolenic acid.

24

Double bonds in FA chains produce what?

kinks and bends

25

Due to kinks and bends in unsaturated FA ... this causes what?

1) Unsaturated FA are LESS packed VS saturated 2) LESS ordered packing = WEAKER intermolecular interactions (vanderwall forces) 3) LOWER melting points for unsaturated fatty acids.

26

Which fatty acids can humans not synthesize? Why do we need them?

LinoLEIC acid, Omega 6. LinoLENIC acid, Omega 3. Need them to synthesize other needed FA, such as AA, DHA, EPA and n-3 and n-6 eicosanoids.

27

Importance of omega 3?

-inhibit formation of thromboxane A2 (eicosanoids) -> associated with platelet aggregation + clot formation.

28

Omega 3 FA are associated with decrease risk of what disease?

Coronary diseases

29

3 major typed of omega 3 fatty acids?

-alpha linolenic cid (ALA) -EPA -DHA

30

What are the effective PUFA's?

EPA DHA