Liver - ontogenesis (including the embryogenesis) Flashcards
(43 cards)
When does the development of the liver begin during embryogenesis?
The development of the liver begins around the third week of gestation.
Where does the liver originate during embryogenesis?
The liver originates from the endodermal layer of the foregut, which is part of the early embryonic digestive tube.
What is the hepatic diverticulum?
The hepatic diverticulum is an outgrowth from the foregut that eventually develops into the liver and its biliary system (bile ducts).
What is the role of the mesoderm in liver development?
The mesoderm contributes to the formation of the connective tissue, blood vessels, and hepatic sinusoids in the liver.
What do the hepatic cords and bile ducts form in liver development?
The hepatic cords form hepatocytes (liver cells), while the bile ducts develop from the cells of the hepatic diverticulum to transport bile.
When does the liver start producing bile during development?
The liver starts producing bile around week 12 of gestation.
How does the liver’s blood supply form?
The liver’s blood supply develops from the hepatic artery (from the abdominal aorta) and the portal vein (from the gastrointestinal tract).
What is the hepatic diverticulum and its significance in liver development?
The hepatic diverticulum (or liver bud) is the outgrowth from the foregut that eventually forms the liver and its biliary system (bile ducts).
What is the role of the mesoderm in liver formation?
The mesoderm contributes to the connective tissue, blood vessels, and the hepatic sinusoids in the liver, and forms Glisson’s capsule, which surrounds the liver.
At which day of embryonic development does the hepatic diverticulum begin to form?
The hepatic diverticulum begins to form around day 22 of embryonic development.
What is the role of the splanchnic mesoderm in liver development?
The splanchnic mesoderm contributes to the formation of the liver’s blood vessels, connective tissue, and the liver’s sinusoids (specialized capillaries).
What is the function of the hepatic sinusoids in the liver?
The hepatic sinusoids are specialized blood vessels that allow for the exchange of nutrients, waste products, and oxygen between the blood and hepatocytes (liver cells).
When do the liver’s hepatocytes first appear?
Hepatocytes (liver cells) first appear during week 4-5 of embryonic development as the liver begins to differentiate and form functional tissue.
What important function does the liver take over during early fetal development?
During early fetal development, the liver is responsible for hematopoiesis (blood cell production), a role it continues to perform until the bone marrow takes over later in pregnancy.
At what stage does the liver begin bile production during fetal development?
The liver begins bile production around week 12 of fetal development.
What is the biliary system and how does it develop?
The biliary system, which includes bile ducts, develops from the cells of the hepatic diverticulum (liver bud) as it forms and differentiates.
How does the liver’s blood supply begin to form?
The liver’s blood supply begins with the formation of the hepatic artery (from the abdominal aorta) and the portal vein (from the gastrointestinal tract), which bring oxygen-rich and nutrient-rich blood to the developing liver.
What is the role of the portal vein in liver development?
The portal vein carries nutrient-rich blood from the digestive system to the liver, allowing the liver to process the nutrients absorbed from digestion.
How does the liver’s gallbladder develop?
The gallbladder develops from the biliary tree, a branching structure that originates from the hepatic diverticulum. It starts forming by week 4 of fetal development.
When does the liver start developing during embryogenesis?
The liver starts developing around week 3 of gestation, during the embryonic stage.
What happens by the end of the first trimester regarding liver function?
By the end of the first trimester, the liver is capable of producing bile and performing its basic
How does the liver’s function mature during the second trimester?
During the second trimester, the liver matures and takes on more functions, such as detoxifying blood,
At birth, what functions does the liver perform for the newborn?
At birth, the liver continues to perform essential functions like detoxification, metabolism, and hematopoiesis (blood cell production), although hematopoiesis shifts to the bone marrow shortly after birth.
What happens to the liver after birth?
After birth, the liver continues to mature, refining its functions in nutrient storage, enzyme systems for detoxification, and bile production to support the child’s growth and immune functions.
