Liver Part 1 Flashcards Preview

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Flashcards in Liver Part 1 Deck (20):
1

What are the two main detoxifying pathways of the liver?

cytP450
glutathione

2

What are 5 responses seen in liver disease?

1. Degeneration and intracellular accumulation
2. necrosis and apoptosis
3. inflammation
4. regeneration
5. fibrosis

3

Degeneration and intracellular accumulation

- swelling hepatocytes
- ballooning degeneration

4

What are 3 types of toxic intracellular deposition?

hemochromatosis
wilsons disease (copper)
steatosis

5

What types of cells are seen in iron deposition?

Kupfer cells and hepatocytes filled with granular brown deposits of hemosiderin

6

What type of cells are seen with necrosis and apoptosis?

councilman bodies:
- coalesced shrunken hepatocytes
- intense eosinophilic staining and fragmented nuclei

7

fibrosis

fibrous tissue formed in response to inflammation
- not usually reversible
- deposition of collagen
- scar tissue = cirrhosis

8

3 non hepatitis viruses that involve the liver?

- epstein-barr virus (EBV)
- cytomegalovirus
- yellow fever

9

Hep A

acute
fecal oral

10

Hep B

acute or chronic
cirrhosis
iv drug users
only DNA hep virus

11

What is the only DNA hep virus?

Hep B

12

What hep increases risk for developing hepatocellular carcinoma?

Hep B
Hep C

13

Hep C

acute or chronic
IV drug users
hepatocellular carcinoma
cirrhosis
chronic carrier (more likely than hep B)

14

#1 cause of hep in US?

Hep C

15

Surpa infection?

get hep B, then hep D

16

Co infectino

get hep B and D at the same time

17

What is a sequelae of fulminant liver?

hepatic encephalopathy

18

What can hep E lead to in pregnant women?

fulminant hepatic necrosis with fatality

19

Drug-induced acute hep

asprin causes

20

Reyes Syndrome

acute hep with severe inflammation and fate deposition in liver
- usually dx in children