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Flashcards in Local Anesthetics Deck (29)
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1
Q

Local anesthetics produce tranisent loss of _____,_____,_____ ?

A

Sensory, Motor, Autonomic Function

2
Q

Local anesthetics produce a conduction block by preventing passage of _____ through selective channels in the nerve membrane?

A

Na+

3
Q

What is responsible for the speed of a local anesthetics onset?

A

PKa

4
Q

The unionized portion of the drug is _____ and is what actually gets into the cell

A

Lipophilic

5
Q

Once the lipophilic portion of the drug gets into the cell it redistributes into _____ and _____ based on the Ph inside the cell and the drugs PKa.

A

Ionized and Nonionized

6
Q

Most local anesthetics are _______ and range from _____ to ____ PKa?

A

Weak Bases

8.0-9.0

7
Q

Most drugs are weak bases but this drug we give in anesthesia is a weak acid?

A

Sodium Thiopental

8
Q
A

Base

9
Q
A

Acid

10
Q

Drug PKa is 8.2 and is injected IV in normal Patient with a PH of 7.4. Does the curve shift to the right or left and what portion increaes Ionized or nonionized?

A

Shifts to the Left

Increasing nonionized portion

11
Q

The primary active sight of a local anesthetic is where?

A

Intracellular

12
Q

Which part of the local anesthetic binds to the receptor site the anion or cation?

A

cation

The charged portion

13
Q

Potency correlates with what in the local anesthetic?

A

Lipid solubility therefore the nonionized portion

14
Q

Durration of action depends on what?

A

The amount of the drug protein bound to the channel not refering to protein binding intravascularly because the drug is in the cell at this point

15
Q

Which Local anesthetic is only used in its S enantiomer form?

A

Ropivacaine

16
Q

which local anesthetic is achiral?

A

Lidocaine

17
Q

Local anesthetics are either ______ or _____?

A

Esters or Amides

18
Q

Addition of Epi does 3 things what are they?

A

Prolong the Block

Increase intensity of the Block

Decrease systemic absorption of the LA

19
Q

Local anesthetics are composed of 3 parts ?

A

Lipophilic Group, Amide or Ester, Hydrophilic Group

20
Q

NO Question Just view it

A

NO Answer Just view it

21
Q

Amides are metabolized where?

A

Liver

22
Q

Esters are metabolized where?

A

Plasma Cholinesterase

23
Q

Ester or Amide

A

ESTER!!!!

24
Q

Ester or Amide

A

ESTER

25
Q

Ester or Amide

A

AMIDE

26
Q

Ester or Amide

A

AMIDE

27
Q

Amides are Metabolized 3 ways?

A

N-dealkylation, Amide Hydrolysis, Aromatic Hydroxylation

28
Q

List all Ester Local anesthetics?

A

Cocaine, Benzocaine, Procaine, Tetracaine, Chloroprocaine

29
Q

List local anesthetics that are common Amides

A

Lidocaine, Bupivacaine, Ropivacaine, Mepivacaine, Prilocaine,