LOCO LA Flashcards
(220 cards)
Supporting limb laminitis is due to ….
poor peripheral perfusion
Is supporting limb laminitis also due to mechanical overload?
NO
Is equine laminitis a disease?
No it is a syndrome
What is the most common cause of equine laminitis?
endocrinopathic- hyperinsulinemia
Does glucose toxicity and deprivation contribute to endocrinopathic laminitis?
No it does not.
What are the 3 causes of endocrinopathic laminitis?
1- PPID
2- GC
3- Equine Metabolic Syndrome
Can prednisolone or other corticosteroids initiate laminitis in a horse?
No, unless the horse is predisposed to hyperinsulinemia. Prednisolone can increase the chance of recurrence only.
What causes the Pars Intermedia in the horse to secrete more cortisol and CLIP hormones in laminitis?
loss of DA inhibition
What are the mechanisms that lead to loss of hemidesmosomes in the equine foot leading to inflammatory laminitis?
1- Inflammation (cytokine release, leucocyte adhesion, endothelial activation)
2- Hypoxia
Lead to structural damage
Medical treatment for PPID
Pergolide
Medical management of sepsis induced laminitis in horses
- anti-endotoxins
- digital cryotherapy
- treat underlying cause
Prevention for EMS laminitis in horses
- Reduce NSC consumption
- exercise
- weight loss
What do all horse laminitis cases have?
Bounding pulses
Is equine laminitis an emergency?
Yes
Prognosis of equine laminitis will depend on
- previous history
- severity of coronary band depression
- degree of pedal bone rotation
Can OA be cured?
NO
Degenerative joint disease is a … process
inflammatory
In Degenerative joint disease which structures produce inflammatory cytokines leading to matrix breakdown?
All of them
In Degenerative joint disease (DJD), what increases and decreases (water, collagen, proteoglycans)
- water increases
- collagen decreases
- proteoglycans decrease
is synovitis and joint distention painful?
Yes
Where are the pain receptors located in a joint?
- The subchondral bone and the joint capsule
- NO receptors on the articular cartilage
Does the articular cartilage have pain receptors?
No
What are the goals treatment in DJD?
- stop inflammation
- restore joint function
- reduce pain
- chondroprotection (disease modifying drugs)
What questions when hx taking would you ask when assessing a lame horse?
- How many limbs? 1, 2, multiple?
- other horses affected?
- history of trauma
- behavioural changes before?
- onset?
- duration?