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Flashcards in Lung Cancer Deck (24):
1

Squamous Cell Carcinoma

p53 highest frequency of all lung cancers
Rb1
EGFR overexpression
deletions of 3p, 9p, 17p

2

Adenocarcinoma

produce TTF-1 and mucin
KRAS mutations = poorer outcome
EGFR (targeted therapy)
similar frequency as p53, Rb1, p16

3

Bronchoalveolar Carcinoma (Adenocarcinoma In Situ)

dysplastic cells growing along alveolar septa
lepidic growth, histologically looks like thickened alveolar walls

4

3 big papillary cancers?

bladder thyroid ovary

5

3 less common papillary cancers?

liver lung colon

6

Small Cell Carcinoma (Oat Cell)

SUBmucosal, central.
Squamous was central & mucosal.
mutations of p53, Rb1
HIGH LEVELS of ANTI-APOPTOTIC PROTEIN BCL2!

7

Adenocarcinoma Subtypes

2 subtypes:
Mucinous- spread aerogenously, satellite tumors form when patient coughs, WORSE. (mucinous is BETTER in colon)
Non-Mucinous- solitary

8

neuroendocrine markers

chromogranin, synaptophysin, CD57

9

oncogenes of lung cancer

C-MYC, KRAS, EGFR, c-MET, c-KIT

10

multiple loci on chromosome 3p

many candidate tumor repressor genes, FHIT, RASSF1A and others

11

tumor suppressor genes

p53, Rb1, p16 (INK4a)

12

field cancerization

loss of chromosome 3p material found in benign bronchial epithelium of individuals with lung cancer

13

synchronous primaries

2 primary cancers that occur at the same time

14

metachronous primaries

2 primary cancers that occur at separate times

15

lung cancer in NON-smokers

EGFR mutations
rare KRAS, p53 mutations

16

Locations?

Adeno = subpleural
Oat Cell = submucosal
Squamous Cell = mucosal

17

combined carcinoma

1 cell gave rise-- NOT a collision carcinoma

18

systemic manifestatiosn

lambert eaton
acanthosis nigricans
peripheral neuropathies (sensory)
hypertrophic osteoarthritis
clubbing of fingers

19

Carcinoid tumors

well-behaved neuroendocrine tumors
near MAINSTEM bronchus
submucosal
organoid with delicate fibrivascular stroma
flushing, diarrhea, cyanosis

common in lungs, GI, appendix

20

Anterior Mediastinum

thymoma
teratoma
lymphoma
thyroid/parathyroid
mestastatic carcinoma

21

Posterior Mediastinum

neurogenic (Schwannoma, neurofibroma)
lymphoma
metastatic
bronchogenic cyst
hernia (gastroenteric)

22

Middle Mediastinum

bronchogenic cyst
pericardial cyst
lymphoma

23

Fibrinous exudations

reflect later, more severe exudative reaction that in an earlier development phase might have presented as a serous or serofibrinous exudate

24

Malignant Mesotheliomas

Acid mucopolysaccharide +
CEA -
CK +