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Flashcards in Stuff Deck (36):
1

EGF and TGF alpha

made by keratinocytes, macrophages, inflammatory cells
mitogenic for hepatocytes, fibroblasts, epithelial cells
HER2 overexpressed

2

HGF

made by fibroblasts, CT cells, non-parenchymal liver cells
mitogenic for hepatocytes and epithelial cells
receptor MET overexpressed in tumors (renal & thyroid papillary carcinomas)

3

PDGF

made by macrophages, endothelial cells, SM cells, tumor cells
migration of fibroblasts, SM, monocytes to areas of wound healing

4

VEGF

vascular dilation, increased vascular permeability stimulated by hypoxia

5

Platelet dense granules?

histamine
serotonin
epinephrine
Ca
ADP, ATP

6

Platelet alpha granules?

fibrinogen, fibronectin, factors 5, 8, platelet factor 4 , PGDF, TGF-Beta

7

CML

t(9:22) ABL

8

Burkitt's Lymphoma

t(8:14) c-MYC

9

Rb

-13

10

Wilms' Tumor

-11

11

Neuroblastoma gene amplification

N-myc

12

BRAF

malignant melanoma

13

Epithelial Markers

CEA, keratin, EMA

14

Mesenchymal Markers

vimentin, desmin

15

Nerve, Neuroendocrine Markers

NSE, chromogranins

16

Prostate Cancer

PSA, PAP

17

Lymphomas

LCA, B and T cell markers

18

Endocrine tumors

various hormones

19

CEA

colorectal, pancreatic, liver, gastric cancers

20

AFP

liver and germ cell tumor of testis

21

HCG

chorionic carcinoma, germ cell tumors

22

GFAP

neuroglia

23

S-100

breast

24

CA 19-9

colon, pancreas

25

CA 15-3

breast

26

CA-125

ovarian

27

Metastasis to bone?

prostate, lung, breast, thyroid, kidney

28

metasisis to brain?

lung, breast, kidney

29

which invade veins?

RCC, hepatocellular carcinoma

30

myasthenia

bronchogenic carcinoma

31

neuropathies

breast carcinoma, small cell carcinoma

32

Bradykinin?

vasodilation, increased vascular perm, pain

33

Kallikrein

increased chemotaxis, plasmin generation, increae inflammation

34

Thrombin

thrombin binds to protease-activated receptors
increases inflammatory response:
1. increase endothelial adhesion molecules
2. make cytokines - PAF, NO
3. make PGs

35

plasmin

increases inflammatory response by
cleaving c3
activating hageman factor

36

endothelial cells

endothelin: prolonged vasoconstriction
NO, PGI2: inhibits platelet aggregation, vasodilation