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Flashcards in Zoonoses Deck (11):
1

Yersinia pestis virulence factors

PsaA, YadA, YpkA, Yop H, M

2

PsaA

pilus adhesin, produced maximally at pH 6 (in phagolysosome); chromosomally encoded, 37 degrees

3

YadA

plasmid encoded, 37 degrees; host receptors = beta 1 integrins, laminin, fibronectin

4

Yops

plasmid encoded, antiphagocytic

5

YpkA

ser/thr kinase activity

6

YopH

tyrosine phosphatase activity, inhibits intracellular signaling

7

YopM

indirectly affects signaling by preventing platelets from releasing cytokines

8

YopE

destroys actin monofilaments

9

LcrV

essential for full expression of Yops

10

fraction L Fra1 protein capsule

antiphagocytic and activates complement
plasmid-encoded and expressed mostly at 37 degrees

11

Pla (plasminogen activator)

degrades C3b and C5a
degrades some Yops
dissolves fibrin clots