Paraneoplastic Syndromes Flashcards Preview

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Flashcards in Paraneoplastic Syndromes Deck (13):
1

cushing syndrome

ACTH - SCC of lung, pancreatic carcinoma, neural tumors

2

SIADH

ADH (or ANF)
SCC of lung and intracranial neoplasms

3

hypercalcemia

PTH-RP and TGF-alpha, TNF, IL-1
SCC of lung, breast carcinoma
renal carcinoma, Adult T Cell Leukemia/Lymphoma

4

hypoglycemia

insulin
ovarian carcinoma, fibrosarcoma

5

carcinoid syndrome

serotonin & bradykinin
pancreatic carcinoma and bronchial carcinoma

6

polycythemia

erythropoietin (made by JG cells)
renal cell carcinoma, gastric carcinoma, cerebellar hemangioma, hepatocellular carcinoma

7

myasthenia

bronchogenic carcinoma

8

neuropathies

breast carcinoma, small cell carcinoma

9

acanthosis nigricans (black splotchy plaques that occur in the axillary folds of skin)

gastric carcinoma
lung carcinoma
uterine carcinoma

10

Trousseau's sign - migratory deep vein thrombosis

tumor products -- mucins activate clotting
pancreatic cancer
GI tract, lung cancer

11

clubbing of fingers

lung cancer

12

fever of unknown origin, night sweats

lymphomas (Hodgkin's)
renal carcinoma
osteogenic sarcoma

13

peripheral neuropathy, dermatomyositis

small cell carcinoma of lung