Lymhoma CD markers

Question 1

CLL/SLL

Answer 1

CD19+, CD20+ (dim), CD5+, CD23+,CD200+

+12; del(13q), del(11q), del(17p), del(6q)

Question 2

Mantle cell lymphoma

Answer 2

CD19+, CD20+, CD5+, CD23−, Cyclin D1+

Mantle = minus cd23 and cyclin D1 over expression

t(11;14)

Question 3

Follicular lymphoma

Answer 3

CD19+, CD20+, CD10+, BCL2+, BCL6+

GC: CD10+, BCL2 translocation

t(14;18) - IgH, bcl2

Question 4

Burkitt lymphoma

Answer 4

CD19+, CD20+, CD10+, BCL6+, Ki-67 ~100%

High proliferation; t(8;14); starry-sky histology
C-myc, IgH

Question 5

DLBCL

Answer 5

CD19+, CD20+, variable CD10/BCL6, MUM1+ (ABC type)

CD10+ = GC type; MUM1+ = activated B-cell

Question 6

Marginal zone (MALT, nodal, splenic)

Answer 6

CD19+, CD20+, CD5−, CD10−

NMZL: +3
Splenic MZL: del(7q)

Question 7

Hairy cell leukemia

Answer 7

CD19+, CD20+, CD11c+, CD25+, CD103+

Question 8

Hodgkin lymphoma (classical)

Answer 8

CD30+, CD15+, CD20−, CD45−

Reed–Sternberg: CD30+, CD15+; PAX5 weak+

Question 9

Nodular Lymphocyte Predominant HL

Answer 9

CD20+, CD45+, CD15−, CD30−

Popcorn cells = looks more B-cell than classical HL

Question 10

PTCL-NOS

Answer 10

CD2+, CD3+, CD5+, CD7 loss, CD4 or CD8

Question 11

Anaplastic large cell lymphoma (ALK+)

Answer 11

CD30+, ALK+, CD3−/+

ALK translocation (t(2;5)); hallmark cells

Question 12

Adult T-cell leukemia/lymphoma

Answer 12

CD3+, CD4+, CD25+

HTLV-1 associated

Question 13

IgH, IgK, IgL aka fertilizer

Answer 13

14,2,22

Question 14

C-myc, cyclin D1, bcl2

Answer 14

8,11,18

Question 15

T-cell large granular lymphocytic leukemia (T-LGL)

Answer 15

CD3+, CD8+, CD57+, CD16+, CD5 dim

αβ+

Question 16

Chronic NK-LGL

Answer 16

CD3−, CD56+, CD16+, CD57+

Question 17

Aggressive NK cell leukemia

Answer 17

CD3− surface, cytoplasmic CD3ε+, CD56+, CD2+

EBV pos

Question 18

Extranodal NK/T cell lymphoma (nasal)

Answer 18

CD2+, CD56+, cyto CD3ε+, CD5−, CD4−/CD8−

EBV pos

Question 19

Hepatosplenic T cell lymphoma

Answer 19

CD3+, CD56−, TCR γδ+, CD2+, CD4−, CD8+/−

Question 20

CD8+ PTCL-NOS

Answer 20

CD3+, CD8+, CD2+, CD7−, CD4−, CD5 variable

αβ+ or unknown