Lymph

Question 1

Lymph node- cortex contains

Answer 1

B cells zone. Lymphoid follicles- 1’ & 2’

Question 2

Lymph node paracortex contains

Answer 2

Mainly T cells and

T cell antigen-presenting cells

Question 3

Lymph node- high endothelial venues (HEVs)

Answer 3

Express ADHESION MOLECULES that anchor circulating lymphocytes and also act as tissue specific recognition molecules

Question 4

Lymph node- sinuses

Answer 4

Contain macrophages, capture larges AG / Immune complexes / viruses

Question 5

Lymph node- medullary cords

Answer 5

Contain mainly mature plasma cells

Question 6

B lymphocytes play a key role in

Answer 6

HUMORAL immune response

Question 7

B lymphocytes develop in the ? During fetal life

Answer 7

Liver

Question 8

B lymphocytes develop in the ? During adult life

Answer 8

Bone marrow

Question 9

The name of B lymphocytes receptor

Answer 9

BCR

Question 10

B lymphocytes differentiation, 2 steps

Answer 10

1 somatic mutation & recombination - gene rearrangement for H & L chain variable regions (AG independent phase)

2 generation of high affinity receptors/ ABs. Germinal center reaction of plasma cells and memory B cells (AG dependent)

Question 11

RAG complex

Answer 11

Recombination activating gene- a heterodimeric enzyme
Breaks the ddDNA at specific location of recombination sequences

Has a terminal TdT deoxynucleotidyl transferase that adds N’ nucleotides to recombined VhDJh , at the DJ junction

Question 12

CD4+

Answer 12

MHC II Restricted

Become Th after recognizing EXTRAcellular AG

Question 13

CD8+

Answer 13

MCH I restricted

Become Tct after recognizing INTRAcellular AG

Question 14

Dendritic cells

Answer 14

Antigen presenting cells!!