Renal

Question 1

Hemorrhagic uremia syndrome

Answer 1

Most freq. assoc. with consumption of contaminated food- E.Coli producing shiga like toxin

Question 2

ADAMTS13

Answer 2

a plasma metalloprotease. Regulates func. Of vW. Cleaves vWF multimeters into smaller sizes. Inherited or acq deficiencies(autoAB, gene mut) assoc with thrombotic thrombocytopenia purpura

Question 3

Horseshoe kidney- most frequent in

Answer 3

Turner s

Question 4

Horseshoe kidney

Answer 4

Due to fusion of nephrogenic blasted as during their upward migration in intrauterine life. (Can be asym). Obstruction of ureters and increased risk of pyelonephritis

Question 5

Hence jones protein

Answer 5

Occurs in the urine of pets with certain diseases , specially multiple myeloma

Question 6

Nephritis

Answer 6

Any various acute/chronic inflammation of the kidney. May involve glomeruli/ tubules/ interstitial tissue surrounding them

Question 7

Cystocele

Answer 7

Herniation of the urinary bladder through the wall of the vagina

Question 8

Albumin MW, size

Answer 8

70KDa

~3.6 no Radius!!

Question 9

The glomerular filtration barrier is more permeable to which ions

Answer 9

Cations, positively charged

Question 10

Glomerular disease pathogenesis- options

Answer 10

1. Immune mediated- immune complex deposits causing injury
2. Cell mediated immune injury
3. Activation of the alternative complement pathway causing injury
4. Podocyte injury

Question 11

End stage GLOMERULAR disease is called

Answer 11

CHRONIC glomeruloneohritis, leading to terminal renal failure
Eventual obliteration of the glomeruli- transformed into acellular eosinophilic masses

Question 12

The hallmark of multi cystic renal dysplasia

Answer 12

Primitive cystic ducts

Lined by cuboidal to columnar epithelial cells, surrounded by a collagenous stroma