lymphatic review deck Flashcards
(39 cards)
describe what is found in each part of LN
cortex- afferents, B cells
paracortex- HEVs, T cells
Medullae- efferents, B cells
what is the clinical relevance of the sub capsular sinus?
site of CA mets, macrophages on patrol
how much blood or lymph must be filtered to generate an antigenic response?
5%
what are present in splenic sinusoids?
rod cells, macrophages
how does the spleen receive blood?
central arteriole with PALS
where are Hassal’s corpuscles found?
thymic medulla
where are NKCs stored?
liver, blood, spleen
what region of the antibody will bind to the immune cell?
Fc region on the heavy chain
what links the heavy and light chains of the antibody?
disulfide bonds
what are the 4 functions of antibodies?
identify
opsonize
neutralize
clear infection
which antibody is assoc with mucosa and breast milk?
IgA
which antibody crosses placenta?
IgG
describe MHC-I
present on most cells, presents to killer T cells
describe MHC-II
present only on APCs (macrophages, b cells and dendritic cells), present to T cells
how is they thymus structurally different from all other lymph tissues?
it is not supported by reticular fibers, it instead has thymic epithelial cells
where are the thymic epithelial cells most concentrated?
cortex of thymus
what is the fxn of thymic epithelial cells?
secrete polypeptides
structure/support
what is the structure of the blood-thymus barrier?
continuous capillaries, 2 basal laminae, thymic epithelial cells all held together with tight junctions
how do immature T cells reach the thymus?
circulatory system
is the thymus a lymph filter?
no, as it lacks afferent lymphatics
describe follicular dendritic cells
present in follicles
present antigens on MHC-I
how does most lymph enter secondary lymphatic tissues?exception?
via High endothelial venules, except for spleen
where are cancer cells first noted in LN?
subcapsular sinus
what is a defining feature of tonsils, in general?
crypts
