Lymphatic System Flashcards
(20 cards)
What are the 4 features of inflammation?
- Redness
- Heat (from vasodilation)
- Swelling (from vascular permeability)
- Pain
Loss of function could be 5th
What are the 2 significant differences between lymphocytes and peripheral blood leuokocytes?
- Lymphocytes come from common lymphoid progenitor cell (not common myeloid progenitor)
- Longer life span
Which WBC is most prominent in children? Why?
Lymphocytes
Lymphocytes help to develop your immune system as a kid
Humoral immunity
B lymphocytes active in response to antigens, become plasma cells and secrete antibodies
First response of adaptive immunity
What are the 2 mechanisms of adaptive immunity?
Humoral immunity and cell-mediated immunity
Cell-mediated immunity
Cells react to different antigens and start cascade to kill the antigens
T-helper cells secrete cytokines that recruit cytotoxic T cells and NK cells
Which mechanism of adaptive immunity is responsible for transplant rejection?
Cell-mediated immunity
Describe the 3 characteristics of the lymphatic system
Recognition - self vs. foreign antigens
Specificity - subsets of cells recognize specific antigens
Memory - cells responsive to antigens created to deal with future exposures
Antibodies
Bind to antigen to target it for destruction
Made by plasma cells (activated B cells)
Cytokines
Polypeptides synthesized by mainly T cells (large granular lymphocytes, mononuclear phagocytes, tissue cells) that effect other immune cells
Ex: chemotactic factors, mitogenic agents, interferons, interleukins
Complement
Plasma proteins that bind to antigens and mark them for destruction
Interleukins
Promote growth and differentiation of T /B and hematopoietic cells
Interferons
Small proteins / glycoproteins produced in response to an antigen
Primary lymphocyte organs
Where lymphocytes develop
Thymus (T lymphocytes) and bone marrow (B lymphocytes)
20-30% of circulating lymphocytes are ___.
B cells
Where were B cells first seen?
Bursa of Fabricus (similar to bone marrow for birds)
B cell functions
- -Produce/secrete immunoglobulins
- -Express B-cell receptors (membrane-bound Abs; IgM [immature], IgD [mature]) that act as antigen binding sites
- -Express MHC II (antigen-presenting)
- -Express CD19 (differentiates B cells from other types of cells)
What do B cells express that is unique to that cell type?
CD19
B cells are not antigen-presenting cells. T/F
False, B cells express MHC II
The B cell receptors expressed on mature B cells is ___, while immature B cells express ___.
IgD, IgM
