Lymphoma: Hodgkin, Non Hodgkin Flashcards
1
Q
Lymphoma
- pathophysiology
- types
- presentation
- diagnosis
- management
A
Genetic mutation in lymphocytes/HIV, EBV => cell division in LN/other tissues
Hodgkins - nodal lymphoma that spreads from node to node => treatment can be more targetted (better prognosis)
-Reed Sternberg cells
Non-Hodgkin - non contiguous spread
B symptoms
Confirmation, typing - LN biopsy
Stage - CT, PET
Chemo, stem cell transplant, RT
2
Q
Hodgkin lymphoma
- pathophysiology
- types
- presentation
- diagnosis
- management
A
B cells (Reed Sternberg cell - owl eyes due to 2 nuclei)
B symptoms, cervical LN
Diagnosis - CT, PET, LN biopsy
Rituximab (CD20) => apoptosis
3
Q
Non-Hodgkin lymphoma
- types
- presentation
- diagnosis
- management
A
B cell lymphoma - MOST COMMON
-t(14:18) BCL2 gene, EBV (Burkitt),
T cell lymphoma
-HTLV
Painless LN B symptoms Extranodal GI - bowel obstruction Extranodal BM - BM failure Extranodal SC - motor/sensory deficit in legs
Diagnosis - CT, PET, LN biopsy
Rituximab (CD20) => apoptosis
4
Q
Metastatic spread
A
Liver
Lungs
Bone marrow
