Making a Neuron

Question 1

What specification is needed to make a neuron

Answer 1

specification of neurectoderm & neuroblasts

Question 2

What does neurectoderm become in drosophila CNS

Answer 2

neurons & epidermis

Question 3

Where does the nervous system form in drosophila

Answer 3

ventral side

Question 4

What is a ganglion

Answer 4

collection of neurons

Question 5

What are proneural clusters

Answer 5

groups of cells in neurectoderm

Question 6

What is the position of proneural clusters determined by

Answer 6

AP & DV axis

Question 7

What is the primary fate of proneural clusters

Answer 7

neuroblast

Question 8

What is the secondary fate of proneural clusters

Answer 8

epidermis

Question 9

How do neurectoderm form neuroblasts

Answer 9

lateral inhibition

Question 10

What mediates lateral inhibition

Answer 10

delta-notch signalling

Question 11

How does signalling via delta effect notch

Answer 11

cleavage of notch intracellular domain

Question 12

Example of an equivalence group

Answer 12

proneural cluster

Question 13

Why is a proneural cluster an equivalence group

Answer 13

because all cells have the same potential

Question 14

Describe the phenotype caused by over production of neuroblasts

Answer 14

lethal

Question 15

What does notch code for

Answer 15

receptor protein

Question 16

What does delta code for

Answer 16

tethered transmembrane protein

Question 17

What type of signalling do delta-notch exhibit

Answer 17

juxtacrine

Question 18

What is the effect of cleavage events on delta notch signalling

Answer 18

notch intracellular domain cleaves & becomes part of transcription factor

Question 19

What feedback loop is exhibited by delta-notch

Answer 19

positive feedback loop

Question 20

What is the advantage of using positive feedback for delta-notch signalling

Answer 20

amplifies difference

Question 21

TRUE or FALSE - Delta can diffuse

Answer 21

FALSE

Question 22

Describe the division of neuroblasts

Answer 22

asymmetric

Question 23

What type of cell are neuroblasts

Answer 23

stem cells

Question 24

What innervates mechanosensory bristles

Answer 24

sensory neurons

Question 25

What are the cell types in sensory bristles

Answer 25

sensory neuron, hair cell, socket cell and sheath cell

Question 26

What inhibits notch activity

Answer 26

numb

Question 27

What does over expression of notch cause in sensory organ precursors

Answer 27

four socket cells

Question 28

What does loss of notch function cause in sensory organ precursors

Answer 28

four neurons

Question 29

what is the function of the growth cone

Answer 29

helps axon find targets

Question 30

What is the effect of repulsive cues on the axon

Answer 30

turn axon away

Question 31

What act as long range cues

Answer 31

diffusible molecules

Question 32

What act as short range cues

Answer 32

cell surface molecules E.G. cadherins

Question 33

What does the growth cone use to explore the environment

Answer 33

filopodia

Question 34

How are neural connections refined

Answer 34

pruning and cell death