Flashcards in Malabsorption Deck (28):
Uncommon causes of malabsorption?
Pancreatic cancer, parasites, bacterial overgrowth
Trypsinogen deficiency can lead to what?
Deficiency in amino acid transport
Atrophic gastritis may cause malabsorption of what?
Vitamin B12 due to decreased levels of acid secretion
What may lead to folic acid malabsorption
Diseases affecting the proximal small bowel (celiac disease, whipple, sprue, alcoholism)
Fat soluble vitamins
Acrodermatitis enteropathica can cause decreased absorption of what?
Zinc (this condition is a defect in the zinc transport protein)
Symptoms: rash (peri-oral and acral), alopecia
Defects in HLA-DQ2 and HLA-DQ8 associated with what?
Diagnosis of coeliac disease
IgA anti-tissue transglutaminase test and biopsy
Deficency in lactase causes what?
Confirmation of lactose intolerance?
Lactose breath hydrogen test
Treatment of Tropical Sprue?
Tetracycline and folic acid.
(tetracycline 250mg 6-hourly for 28 days)
Diagnosis of Whipple's disease?
Demonstration of Tropherymia whipplei in involved tissues by microscopy
Treatment for Whipple's disease?
IV ceftriaxone, oral co-triamoxazole (anti-microbials)
Risk factors for Giardia lamblia?
Travelling to places where water supply may be contaminated, swimming in ponds
Treatment for Gardia lamblia?
Metronidazole 1 week
Treatment of other parasites
What bacteria may cause bacterial overgrowth?
E.coli or bacteroides
What may E.coli or bacteroides cause?
Low cobalamin and high folate sign of what?
What does bacterial overgrowth cause?
Diarrhoea, steatorrhoea, macrolytic anemia
Schilling test best for diagnosing what?
Look for bacteria in jejunal aspirate obtained by intubation
When to suspect malabsorption?
In these disease states -> liver, pancreas and small bowel
Past medical history which may lead to malabsorption
Gastric/small bowel resection, gastrointestinal diversion (bariatric), radiation, travel
Vitamin C and K deficiencies may cause what?
Dermatitis herpetiformis may indicate what?
Coeliac disease. Sub-epithelial IgA deposition
Glossitis and angular stomatitis caused by what?
B vitamin and iron deficiency