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Flashcards in Malabsorption Deck (28):
1

Uncommon causes of malabsorption?

Pancreatic cancer, parasites, bacterial overgrowth

2

Trypsinogen deficiency can lead to what?

Protein malabsorption

3

Hartsnup Disease

Deficiency in amino acid transport

4

Atrophic gastritis may cause malabsorption of what?

Vitamin B12 due to decreased levels of acid secretion

5

What may lead to folic acid malabsorption

Diseases affecting the proximal small bowel (celiac disease, whipple, sprue, alcoholism)

6

Fat soluble vitamins

ADEK

7

Acrodermatitis enteropathica can cause decreased absorption of what?

Zinc (this condition is a defect in the zinc transport protein)
Symptoms: rash (peri-oral and acral), alopecia

8

Defects in HLA-DQ2 and HLA-DQ8 associated with what?

Coeliac disease

9

Diagnosis of coeliac disease

IgA anti-tissue transglutaminase test and biopsy

10

Deficency in lactase causes what?

Lactose malabsorption

11

Confirmation of lactose intolerance?

Lactose breath hydrogen test

12

Treatment of Tropical Sprue?

Tetracycline and folic acid.
(tetracycline 250mg 6-hourly for 28 days)

13

Diagnosis of Whipple's disease?

Demonstration of Tropherymia whipplei in involved tissues by microscopy

14

Treatment for Whipple's disease?

IV ceftriaxone, oral co-triamoxazole (anti-microbials)

15

Risk factors for Giardia lamblia?

Travelling to places where water supply may be contaminated, swimming in ponds

16

Treatment for Gardia lamblia?

Metronidazole 1 week

17

Treatment of other parasites

Coccidial, strongyloides

18

What bacteria may cause bacterial overgrowth?

E.coli or bacteroides

19

What may E.coli or bacteroides cause?

Bacterial overgrowth

20

Low cobalamin and high folate sign of what?

Bacterial overgrowth

21

What does bacterial overgrowth cause?

Diarrhoea, steatorrhoea, macrolytic anemia

22

Schilling test best for diagnosing what?

Bacterial overgrowth.
Look for bacteria in jejunal aspirate obtained by intubation

23

When to suspect malabsorption?

In these disease states -> liver, pancreas and small bowel

24

Past medical history which may lead to malabsorption

Gastric/small bowel resection, gastrointestinal diversion (bariatric), radiation, travel

25

Vitamin C and K deficiencies may cause what?

Easy bruising

26

Dermatitis herpetiformis may indicate what?

Coeliac disease. Sub-epithelial IgA deposition

27

Glossitis and angular stomatitis caused by what?

B vitamin and iron deficiency

28

What causes spooning of nails?

Iron deficiency