Male reproductive Flashcards

Question

Tamsulosin (Flomax) class

Answer 1

Alpha1-Adrenergic Antagonists

Answer 2

Relaxes smooth muscle cells Selective for alpha receptors in the prostate

Answer 3

Dynamic obstruction of urethra

Answer 4

Well tolerated Abnormal ejaculation

Answer 5

Prototype: dutasteride and tansulosin FDA approved for BPH

Answer 6

Combining a 5-alpha-reductase inhibitor with an alpha blocker is superior to either agent alone

Answer 7

Most common male cancer in US 2nd to lung cancer in cancer related death Varies among races African-American men = highest Asians and Native American men = lowest Incidence increases rapidly after 50 \> 80% of all cases in men \> 65 yo

Answer 8

Age Familial tendency High fat diet

Answer 9

Early Later BPH type presentation Metastasis Bone Lungs Prognosis Stage dependent Early diagnosis

Answer 10

Prostate cancer is a common cause of cancer death BUT many cases of prostate cancer never become clinically relevant Most prostate cancers grow so slowly that men die of other causes PSA screening was widely adopted before we had evidence for supporting its use

Answer 11

Small survival benefit with PSA screening in randomized trials Use of the PSA test was associated with a 50% drop in prostate cancer deaths in the U.S.

Answer 12

Would take 48 diagnoses of prostate cancer to prevent 1 death Only 1 in 3 men with a positive PSA will have prostate cancer Many unnecessary biopsies Side effects of unnecessary treatment include erectile dysfunction, urinary incontinence, bowel problems

Answer 13

Low, intermediate, and high-grade CA Severity depends on a couple things: Gleason score (higher = worse) Tumor volume PSA Level (higher and rapid rise = worse) Number of “cores” positive (more = worse)

Answer 14

Inability to achieve or sustain an erection sufficient for satisfactory sexual intercourse

Answer 15

Primary (rare) Secondary (most common)

Answer 16

Life-long inability to have a normal erection: Severe psychiatric problems Early vascular trauma

Answer 17

ED in someone with a history of normal erections

Answer 18

Peripheral vascular disease •Arterial insufficiency •Excessive venous drainage •Sedentary lifestyle (risk factor) Medications •Antidepressants •Antihypertensives Endocrine problems Trauma, Surgery (Radical prostatectomy)

Answer 19

Depression Low desire Performance anxiety Strained relationship

Answer 20

Sexual arousal \_PNS and nitric oxide release Activation of cGMP Relaxation of arteries and smooth muscles Increased inflow and reduced outflow Engorgement and erection

Answer 21

PDE-5 Inhibitors

Answer 22

Inhibits PDE5 Increases and preserves cGMP levels Only enhances the normal response to sexual stimuli

Answer 23

Relief of ED Pulmonary arterial hypertension BPH

Answer 24

up to 4 hours before ssexual activity (onset 30-60 minutes)

Answer 25

most common HA (16%) flushing (10%) dyspepsia (7%)

Answer 26

preexisting CV disease if on nitrate Rx hypotension

Answer 27

Do not take if you are taking any nitrates If you have chest pain or other signs of a heart attack during sex, stop and call 911 Sudden loss of vision in one or both eyes, sudden loss of hearing No more than once per day Priapism - erection is painful or lasts more than 4 hours - medical emergency

Answer 28

Germ cell tumors

Male reproductive Flashcards

(53 cards)