Manipulation of the Immune Response Flashcards Preview

Immunology > Manipulation of the Immune Response > Flashcards

Flashcards in Manipulation of the Immune Response Deck (10):
1

What is required for the creation of vaccines?

The mechanism of the disease must be known

2

How is gene polymorphism important in immune responses?

MHC-antigen presentation dictates how the immune system responds

3

What are the 3 mechanisms by which tumors are recognized?

-Mutant surface protein
-Overexpression of protein
-Modified proteins

4

What does the survival of tumors indicate?

They cannot be recognized by the immune system or they have mechanisms to thwart the immune response against them

5

What is the importance of CCL21?

It is secreted by tumors to converts cells into Tregs

6

What is the only remaining defense once tumors thwart T cell responses?

NK cells

7

What is PD-1?

Programmed death receptor that acts as an inhibitor of T cells distinct from CTLA-4

8

What do some tumors display to interact with PD-1?

PDL-1 and 2

9

What happens when PDL-1/2 engages PD-1?

The T cell is killed or paralyzed

10

What is the function of immune checkpoint therapy?

Monoclonal Ab are used to block all T cell inhibitory signals to both CTLA-4 and PD-1 and PD-1 L to block the tumor’s defense