Flashcards in Manipulation of the Immune Response Deck (10):
What is required for the creation of vaccines?
The mechanism of the disease must be known
How is gene polymorphism important in immune responses?
MHC-antigen presentation dictates how the immune system responds
What are the 3 mechanisms by which tumors are recognized?
-Mutant surface protein
-Overexpression of protein
What does the survival of tumors indicate?
They cannot be recognized by the immune system or they have mechanisms to thwart the immune response against them
What is the importance of CCL21?
It is secreted by tumors to converts cells into Tregs
What is the only remaining defense once tumors thwart T cell responses?
What is PD-1?
Programmed death receptor that acts as an inhibitor of T cells distinct from CTLA-4
What do some tumors display to interact with PD-1?
PDL-1 and 2
What happens when PDL-1/2 engages PD-1?
The T cell is killed or paralyzed