Marantic endocarditits

Question 1

definition

Answer 1

nonbacterial thrombotic endocarditis

Question 2

epidemiology

Answer 2

common
occurs in 75% pts w/ malignant tumors (esp. mucinous adenocarcinomas)
common in pts w/ DIC, chronic sepsis, and Swan-Ganz right heart catheterization

Question 3

Pathology

Answer 3

small (1-5mm) fibrin and platelet thrombi
most commonly on atrial side of mitral valve, usually on line of valve closure

second most common site is on ventricular side of aortic valve

Question 4

incidence of infection marantic endocarditis and rheumatic disease on valve correlates w/…

Answer 4

resting pressure on closed valve:

• -mitral=116mmHg
• -Aortic=72mmHg
• -Tricuspid=24mmHg
• -Pulmonic=5mmHg

Question 5

hard work (on valves) leads to…

Answer 5

injury, inflammation, clot deposition, and infection

Question 6

complications

Answer 6

systemic emboli (in about half of cases) to:

• -kidneys
• -spleen
• -brain
• -gut
• -heart

infection
(converts it to infective endocarditis)

Question 7

Important b/c…

Answer 7

1. it is common
2. frequently embolizes
3. precursor to infective endocarditis