Sudden Cardiac death and general

Question 1

asystole

Answer 1

total lack of cardiac pumping

Question 2

Broad causes of sudden death

Answer 2

mechanical pump failure

cardiac electrical signaling failure

Question 3

Sudden cardiac death…epidemiology

Answer 3

3 X more common in males
more common in AA (lower in Hispanics and Asians)
incidence increases w/ age

Question 4

Aproximately 80% of sudden cardiac deaths are attributed to…

Answer 4

CAD

Question 5

second most common cause of sudden cardiac death

Answer 5

Hypertensive heart disease

Question 6

Other causes of sudden cardiac death

Answer 6

myocarditis
channelopathies (hereditary diseases of the cardiac conduction system)
hypertrophic cardiomyopathy
idiopathic dilated cardiomyopathy
cardiac sarcoidosis
cardiac amyloidosis
RV cardiomyopathy

Question 7

Sudden cardiac death is usually due to…

Answer 7

ventricular tachyarrhythmia

Question 8

channelopathies

Answer 8

diseases of Na, K, or Ca ion channels

Question 9

right ventricular cardiomyopathy

Answer 9

associated w/ mutations in genes for cell adhesion proteins

important for low-resistance gap junctions b/w cardiac myocytes, vital for signal conduction b/w cells

Question 10

Familial catecholeminergic polymorphic ventricular tachycardia

Answer 10

associated w/ mutations in genes for ryanodine receptors