Flashcards in Mechanisms of action of anti-parasite drugs Deck (11)
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1
Which NTs do antiparasite drug mimick the action of?
-Ach
-GABA
-Serotonin
- Glu
-Octopamine (OA)
2
Give some examples of how antiparasite drugs can alter metabolic processes
-Inhibit microtubule synthesis
-Uncoupling of oxidative phosphorylation
-Inhibit chitin synthesis
-Inhibit DNA synthesis
3
What are endectocides?
Combine activity against internal and external parasites, offering greater convenience and broader spectrum metazoan parasite control
4
What are the different groups of anthelmintics?
Group 1: white drenches (BENZIMIDAZOLES)
Group 2: yellow drench (LEVAMISOLE)
Group 3: clear drenches (MACROCYCLIC LACTONES- AVERMECTINS/ MILBEMYCINS)
Group 4: Orange drench (MONEPENTAL- ZOLVIX)
5
What is benzimidazoles mode of action?
Microtubule inhibitioin
-bind to tubulin which inhibits polymerization, affects homeostasis
(resistance: nucleotide change in target molecule leading to Aa substitution.
6
Describe Levamisole
- Action is on the nicotinic Ach receptor
- Causes depolarisation and spastic paralysis
- Toxic to some dogs
7
Describe macrocyclic lactones
-e.g. milbemycin/ avermectin
- Action is on the glutamate gated chloride channels, keeps them permanently open causing paralysis at pharynx, somatic muscle and uterus
-Collies are hypersensitive due to lack of P-glycoprotein
-Clinical signs= salivation, ataxia, mydriasis, tremor
8
Which macrocyclic lactone drug is safe for collies?
Selamectin
9
What is the mode of action of monepental?
- Binds to MPTL-1 receptors in NEMATODES
-Causing uncontrolled/ constant influx of ions
-Muscle cells depolarise causing paralysis
10
What is the action of Emodepside?
-Binds to specific G-protein coupled receptors= flaccid paralysis of pharynx
11
