Mechanisms of action of anti-parasite drugs Flashcards Preview

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Flashcards in Mechanisms of action of anti-parasite drugs Deck (11)
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1

Which NTs do antiparasite drug mimick the action of?

-Ach
-GABA
-Serotonin
- Glu
-Octopamine (OA)

2

Give some examples of how antiparasite drugs can alter metabolic processes

-Inhibit microtubule synthesis
-Uncoupling of oxidative phosphorylation
-Inhibit chitin synthesis
-Inhibit DNA synthesis

3

What are endectocides?

Combine activity against internal and external parasites, offering greater convenience and broader spectrum metazoan parasite control

4

What are the different groups of anthelmintics?

Group 1: white drenches (BENZIMIDAZOLES)
Group 2: yellow drench (LEVAMISOLE)
Group 3: clear drenches (MACROCYCLIC LACTONES- AVERMECTINS/ MILBEMYCINS)
Group 4: Orange drench (MONEPENTAL- ZOLVIX)

5

What is benzimidazoles mode of action?

Microtubule inhibitioin
-bind to tubulin which inhibits polymerization, affects homeostasis

(resistance: nucleotide change in target molecule leading to Aa substitution.

6

Describe Levamisole

- Action is on the nicotinic Ach receptor
- Causes depolarisation and spastic paralysis
- Toxic to some dogs

7

Describe macrocyclic lactones

-e.g. milbemycin/ avermectin
- Action is on the glutamate gated chloride channels, keeps them permanently open causing paralysis at pharynx, somatic muscle and uterus
-Collies are hypersensitive due to lack of P-glycoprotein
-Clinical signs= salivation, ataxia, mydriasis, tremor

8

Which macrocyclic lactone drug is safe for collies?

Selamectin

9

What is the mode of action of monepental?

- Binds to MPTL-1 receptors in NEMATODES
-Causing uncontrolled/ constant influx of ions
-Muscle cells depolarise causing paralysis

10

What is the action of Emodepside?

-Binds to specific G-protein coupled receptors= flaccid paralysis of pharynx

11

What is the action of praziquantel?

- Binds to B subunit of voltage gated calcium channels
(not all helminths have this subunit so are not susceptible)
- Causes spastic paralysis
-Vacuolation of tegument
-GOOD FOR ECHINOCOCCUS