medical treatments

Question 1

how does carboplatin work?

Answer 1

chelation via intrastrand crosslink

Question 2

how does cisplatin work?

Answer 2

chelation via intrastrand crosslink.

Question 3

What is bevacizumab - Avastin?

Answer 3

An anti-VEGF antibody.

Question 4

Targets for Avastin/bevizumab

Answer 4

• vestibular neuromas

Question 5

What is Ketoconazole and what is it used for?

Answer 5

An antifungal agent. Block adrenal steroid synthesis. Used for ACTH secreting tumors (Cushings disease)

Question 6

Medical therapy for acromegaly?

Answer 6

(surgery is the best initial therapy.)
* Somatostatin analouges
* Pegvisomant = GH analogue, may be used.

Question 7

What does PCV stand for?

Answer 7

P-Procarbazine
C-CCNU = Lomustine
V-Vincristine

Question 8

Which is the only pituitary tumor treated medically and not surgically?

Answer 8

Prolactinoma

Question 9

What is the first line choice of treatment of Prolactinomas?

Answer 9

DA-agonist - Bromocriptine or Cabergoline.

Question 10

Why is Bromocriptine/Cabergoline 1st hand choice for the treatment of prolactinomas?

Answer 10

Dopamin (Bromocriptine is a DA agonist) is a negative regulator of lactotrophs in the anterior pituitary. It inhibits the basally high-secretory tone of the cell.

Question 11

Why is Bromocriptine/Cabergoline 1st hand choice for the treatment of prolactinomas?

Answer 11

Dopamin (Bromocriptine is a DA agonist) is a negative regulator of lactotrophs in the anterior pituitary. It inhibits the basally high-secretory tone of the cell.