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Flashcards in Medications in pregnancy Deck (25):
1

First 2 weeks exposure to teratogen will have what effect on the fetus?

spontaneous abortion or no effect
"all or none"

2

What effect will teratogens have on a fetus during weeks 3-8 of development

organogenesis

this is when teratogens have their greatest effects

3

Diesthystilberstrol

clear cell adenocarcinoma of the vagine, Mullerian duct anomalies

4

Thalidomide

phocomelia

5

Lithium

Ebstein anomaly
-tricuspid leaflets displaced inferiorly
-RV hypoplasia
-tricuspid regurgitation or stenosis
+/- patient foramen ovale

6

ACE inhibitors

Renal/CNS abnormalities, abnormal skull ossification

7

NSAIDs

premature closure of ductus arteriosus (3rd trimester)

8

Antiepileptics

NTD- spina bifida

9

phenytoin

fetal hydantoin syndrome: dysmorphic face, cleft palate, VSD, hypoplastic nails

10

chloramphenicol

gray baby syndrome

11

fluoroquinolones

cartilage toxicity

12

tetracyclines

yellow-brown discoloration of teeth

13

warfarin

nasal hypoplasia, epiphyseal stipping, limb hypoplasia

14

isotretinoin

spontaneous abortion, severe birth defects

15

fetal alcohol syndrome

brain and face:
-dysmorphic facial features: short palpebral fissures, smooth philtrum, vermillion border
-growth retardation
-CNS abnormalities: microcephaly, intellectual deficits, behavioral problems, learning difficulties, impaired executive functioning

avoid alcohol during pregnancy

16

Cocaine

fetal growth restriction
preterm birth
placental abruption
-premature separation of placenta
-painful vaginal bleeding, contractions, abnormal FHTs

17

Opioids

-fetal growth restriction
-preterm birth
-fetal death
-withdrawal: seizures, irritability, tachypnea, failure to thrive

18

Smoking

spontaneous abortion
fetal growth restriction
placental abruption
preterm birth
stillbirth
SIDS

19

Supplements

iron- anemia
folic acid- neural tube defects

20

pain and fever

acetaminophen
not NSAIDS

21

n/v

pyridoxine
doxylamine

22

HTN

methyldopa
labetalol
hydralazine
nifedipine

23

diabetes

insulin

24

anticoagulation

heparin
LMWH

25

corticosteriods

betamethasone
dexamethasone