Mesothelioma Flashcards
(14 cards)
Is asbestos exposure linked to development of mesothelioma in dogs
Yes - dogs whose owners have jobs or hobbies where asbestos exposure happens are at greater risk
What type of asbestos particle specifically is linked to mesothelioma? Amphibole vs. chrysotile
Amphibole
What tumor suppressor genes are most frequently inactivated in mesothelioma
CDKN2A
BRCA1
BAP1
NF2
Distant mets are common/rare with mesothelioma
Rare - they seed the body cavity but rarely go elsewhere
What breed is overrepresented with sclerosing mesothelioma
GSDs
What CT finding was specific for neoplasia in a study of 20 dogs? (Although only noted in 3)
Chest wall invasion
Elevation in what in pleural effusion of dogs and cats is sensitive but nonspecific for malignancy and can rule OUT mesothelioma if levels are not increased
Fibronectin
What cellular markers are conclusive for mesothelial cells
NONE - none conclusively define mesothelial cells
What are the most useful mesothelial markers to support diagnosis of mesothelioma in humans
Calretinin
WT1
Cytokeratin 5 and 6
D2-40
30% of mesotheliomas are “null” phenotype and negative for all of these
MST in 5 dogs treated with pericardectomy +/- adjuvant chemo (dox or mito)
13.6m
MST for pericardial mesothelioma with partial pericardectomy
60d
Complication rate and mortality rate for thorascopic pericardial window in 15 dogs (10 idiopathic, 5 neoplastic pericardial effusion)
Complication 25%
Mortality 7%
Depth of penetration of intracavitary chemo
2-3mm
Latency period from exposure to tumor development in people with mesothelioma
12-50y - long latency period
