metabolic bone conditions Flashcards
re osteoporosis, what is T score
T-score = number of standard deviations from the mean young (30 yr) same gender and ethnicity
re osteoporosis, what is Z score
Z-score = number of standard deviations from same age, gender and ethnicity
what defines diagnosis of osteoporosis
T score is -2.5 SD or less
re osteoporosis, who do you use Z score for?
children, young adults and pre-menopausal women or men under 50
why are Vertebral bodies
Femoral neck more susceptible to osteoporosis
high proportion of trabecular bone
anti FGF23 monoclonal antibody. when would you use
BUROSUMAB
Hypophosphatemia leading to osteomalacia eg Tumour Induced Osteomalacia
if osteopenia, do you treat?
only if fracture
denosumab moa and tx schedule
binds to RANKL released by osteoblasts thereby inhibiting formation and activation of osteoclasts
sub cut injection every 6 mo
complication of biphosphonates
atypical #s such as femoral shaft
jaw osteonecrosis
general tx of osteoporosis
ca, vit D, biphosphonates
1st choice in peri-menopausal women osteoporosis tx
Oestrogen replacement
Treatment for at least 5 year
What is a SERM? what is an example? when used?
Selective oestrogen receptor modulator (raloxifene), 2nd line tx osteoporosis
Teriparatide - rPTH
monoclonal antibody binds to RANKL
Denosumab
teriparatide moa
pth analogue. HOWEVER, given intermittently, activates more osteoblasts than osteoclasts. very clever
what is raloxifene. used for?
Selective oestrogen receptor modulator
osteoporosis
