RA Flashcards
what hand joints are affected first in RA
MCPs and PIPs
where do you see lyphocytic infiltration in RA
synovium
which specific lymphocytes are most common in RA
TH17
does synovium have a basement membrane
no
what are most synoviocytes
fibroblast-like connective tisue cells
where is synovial membrane in the joint
at the sides, also continues straight into articular cartilage
what are the minority of synoviocytes
macrophage-like cells
describe normal synovial fluid appearance
acellular
straw coloured
what are the only cells which are normally, sparsely in synovial fluid
primarily neutrophils and a few macrophages
what are the 2 tests on synovial fluid? what do they suggest?
string test - string should be 4-6 cm
clot test - should be clear fluid, solid clot
which cells proliferate in RA in the synovium. What is the consequence
macrophage-like synoviocytes++ and fibroblast-like sunoviocytes creating many more layers of synovium than the normal 1-3
which inflammatory cells go where in RA
neutrophils - synovial fluid
lymphocytes - subintima
synovial joints have a rich network of what sort of capillafies
fenstrated
what is this sign of RA, what is it
Pannus, hyperplasia of synovial membrane creates kind of villi as the membrane folds on itself
what to type A cells differentiate into in active RA
they are similar to macrophages, so easily pushed into osteoclasts
MMPs are important/ What do they do?
Soften cartilage, gets eroded away, then bone is exposed leading to more erosion
describe an overview of the 4 criteria for RA diagnosis in ACR/EULAR criteria
