Metabolism Flashcards

0
Q

What three things can happen to glucose

A
  1. Energy production
  2. Muscles replenish glycogen supply (if needed)
  3. Excess glucose not needed for immediate energy is used for fat synthesis.
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1
Q

After eating, blood glucose levels _________ due to carbohydrate digestion and absorption.

A

Increase

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2
Q

When more glucose is available them is needed immediately the excess _________ formed is converted to fat.

A

Acetyl-CoA

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3
Q

Between meals, the supply of dietary glucose _______

A

Decreases

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4
Q

Between meals, liver _____ is the primary source of blood glucose

A

Glycogen

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5
Q

Muscle glycogen can only be used by the muscle because muscle doesn’t have _________ so glucose can’t go back into blood.

A

Glucose 6 phosphatase

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6
Q

What are the needs that need to be met by blood glucose

A

Liver glycogen
Muscle glycogen
Far formation
Tissue oxidation

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7
Q

_____ _____ can’t be used for net synthesis of new glucose

A

Fatty acids

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8
Q

After dietary glucose is in blood, what three things can happen

A

1) energy production (first)
2) muscle glycogen
3) fat synthesis (last)

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9
Q

In the fed state, glucose leaves the intestine via the hepatic portal vein passing through the liver first. As ____ is being oxidized to ____ it is first oxidized to __#3____ in the pathway of ________. #3 is then oxidized to ________.

A
Glucose
CO2
Pyruvate 
Glycolysis 
Pyruvate 
Acetyl CoA
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10
Q

The liver does not store ______, but Packages them along with ______,_________, and ______ into lipoprotein complexes known as ____.

A
Triacylglycerols 
Proteins
Phospholipids
Cholesterol
VLDL
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11
Q

______ is the one fuel that can be used by all tissues.

A

Glucose

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12
Q

The brain and other neural tissues are very dependably on glucose for their energy needs. They generally _______ glucose via ______ and the _______ _______, completely to _____ and _____, generating _____.

A
Oxidize 
Glycolysis
TCA cycle
CO2
H2O
ATP
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13
Q

______ is the only fuel that can be use by RBC’s becomes they lack _______

A

Glucose

Mitochondria

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14
Q

Glucose generates ATP from ______ ________ in the _____, thus RBC obtain energy. In ________ ________ the ______ formed is converted to _________ and the. Released into blood.

A
Anaerobic glycolysis 
Cytosol 
Anaerobic glycolysis 
Pyruvate 
Lactate
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15
Q

Exercising skeletal muscle can use glucose from the blood of from their own glycogen stores, converting ______ to ________ through _________ or oxidizing it completely to ____ and _____

A
Glucose 
Lactate
Glycolysis 
CO2
H2O
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16
Q

Glucose is transported into muscle cells and converted to _____ by processes that are stimulated by _______.

A

Glycogen

Insulin

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17
Q

______ stimulates the transport if glucose into adipose cells a well as into muscle cells

A

Insulin

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18
Q

After glucose is transported into cells, it is ______ by a ______ to form _____

A

Phosphorylated
Hexokinase
Glucose 6 phosphate

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19
Q

The major fate if G6P is oxidation via the pathway of ________, which provides a source of ____ for all cell types.

A

Glycolysis

ATP

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20
Q

The process of glucose production is _______, which occurs primarily in the ______, is the pathway for the synthesis of glucose from compounds other than __________

A

Gluconeogenesis
Liver
Carbohydrates

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21
Q

The three regulatory steps of glycolysis

A

1) pyruvate to phosphoenol pyruvate (PEP)
2) fructose 1,6 bis phosphate to fructose 6 phosphate
3) glucose 6 phosphate to glucose

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22
Q

After a meal containing carbohydrates, blood glucose levels _________. Some of the glucose from the diet is stored in the ______ as _______.

A

Rise
Liver
Glycogen

23
Q

_______ is elevated during the fed state, and ______ is elevated during fasting.

A

Insulin

Glucagon

24
Fatty acid synthesis is in the _____ of the cell
Cytosol
25
__________ is formed in the mitochondria
Acetyl CoA
26
The two sources for NADPH required for fatty acid synthesis
1) malic enzyme | 2) pentose phosphate pathway
27
Acetyl CoA combines with ________to form ______ to be able to leave the mitochondria
Oxaloacetate | Citrate
28
Once citrate is out if the mitochondria, it is cleaved by ________ lyase to form ______ and ______.
Citrate OAA Acetyl CoA
29
Liver ____ is the primary source of blood _____ during the first few hours of ________.
Glycogen Glucose Fasting
30
As blood glucose levels rise after a mea, the increases glucose conc stimulates the ______ cells of the pancreas to release ______
B cells | Insulin
31
Glucagon levels decrease in response to a high________ meal but try increase in response to a high ______meal
Carbohydrate | Protein
32
During fasting, as blood glucose levels decrease, insulin levels decrease and glucagon levels rise. These hormonal changes cause the ______ to degrade _______ by _______ to to produce _______ by ______ so that blood glucose levels are maintained
``` Liver Glycogen Glycogenolysis Glucose Gluconeogenesis ```
33
Fat acids are synthesized mainly in the ____ on humans, with dietary glucose serving as the major source of _______.
Liver | Carbon
34
The major source of carbon for synthesis of FA is dietary _________.
Carbohydrate
35
The FA synthase complex is located in the ______, so it uses ________.
Cytosol | Cytosilic acetyl CoA
36
The NADPH required for FA synthesis is generated by the________ _________ _______ and from recycling ______ produced by citrate lyase.
Pentose phosphate pathway | Oxaloacetate
37
Fatty acid synthase forms
Palmitate
38
After a meal Blood glucose levels _____ Insulin levels ______ Glucagon levels ______
Decrease Decrease Increase
39
Fasting: liver glycogen is degraded by ________, which supplies ______ to the blood.
Glycogenolysis | Glucose
40
Adipose triacylglycerols are mobilized by the process of _________, which releases _______ and ________ into the blood.
Lipolysis Fatty acids Glycerol
41
The liver partially oxidizes fatty acids to smaller molecules called ______ ______, which are released into the blood
Ketone bodies
42
Major sources of carbon for gluconeogenesis
Lactate Glycerol Amino acid
43
When the carbons of amino aids are converted to glucose by the liver, their nitrogen is converted to _____
Urea
44
When we fast for three or more days we are in the
Starved state
45
Product of glycolysis in RBCS and exercising muscle
Lactate
46
Obtained from lipolysis of adipose TAG
Glycerol
47
________ are the major source on energy during fasting
Adipose TAG
48
The liver lacks an enzyme required for _____ ____ oxidation
Ketone body
49
What are the two most prominent ketone bodies and the one minor
Acetoacetic acid B hydroxy butyrate Minor: acetone
50
What amino acids are completely ketogenic
Leucine
51
What amino acids are both ketogenic and glucogenic
``` Phe Ile Trp Try Lys ```
52
Alanine becomes
Pyruvate
53
Aspartic acid becomes
Oxaloacetic acid
54
Glutamic acid becomes
a keto glutarate