Methylprednisolone (Solu-Medrol) Flashcards

1
Q

Generic/Trade Name

METHYLPREDNISOLONE

A

Solu-Medrol®

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2
Q

Generic/Trade Name

Solu-Medrol®

A

METHYLPREDNISOLONE

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3
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Drug Classification:

A
  • Corticosteroid
  • Anti-inflammatory
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4
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Mechanism of Action:

A

Diffuses across the cell membrane, binds to DNA, regulates gene expression and increases synthesis of proteins and enzymes that inhibit inflammatory agents (cytokines, interleukin, interferon); inhibits synthesis of pro-inflammatory enzymes

*Is an immunosuppressant*

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5
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Onset of Action

A

2-6 hours

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6
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Peak Effects

A

4-8 days

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7
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Duration of Effect

A

1-5 weeks

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8
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Half-Life

A

3.5 hours

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9
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Indications/Field Use:

A
  • Severe anaphylaxis
  • hives
  • Asthma
  • COPD
  • Spinal cord injury
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10
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Contraindications:

A

None EMS

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11
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Side Effects/Adverse Reactions:

A
  • Fluid retention
  • CHF
  • HTN
  • abd. distention
  • vertigo
  • HA
  • nausea
  • malaise
  • hiccups
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12
Q

METHYLPREDNISOLONE (Solu-Medrol®)

ADULT Dose Asthma/Anaphylaxis:

ADULT Dose Spinal cord injury:

A
  • 125-250mg IV, IO
  • 30mg/kg IV, IO over 15min, maintenance 5.4mg/kg/hr for 24-48h
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13
Q

METHYLPREDNISOLONE (Solu-Medrol®)

PEDI Dose Asthma/Anaphylaxis

A

2mg/kg IV, IO, IM; max dose 80mg

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14
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Precautions:

A
  • Give only one dose prehospitally,
  • LT steroid use can cause GI bleeding,
  • prolonged wound healing
  • suppression of adrenocortical steroids
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15
Q

METHYLPREDNISOLONE (Solu-Medrol®)

Drug-Drug Interactions:

A
  • Lasix and thiazide diuretics increase potassium loss;
  • decreased effect with phenytoin, phenobarbital, and rifampin due to increased metabolism of steroids
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