MORPHINE SULFATE

Question 1

Generic/Trade Name

MORPHINE SULFATE

Answer 1

MORPHINE SULFATE

Question 2

MORPHINE SULFATE

Drug Classification:

Answer 2

Narcotic Analgesic

Question 3

MORPHINE SULFATE

Mechanism of Action:

Answer 3

Opiate R agonist ⇒ CNS depression, induces analgesia and sedation, increases peripheral venous capacitance and decreases venous return, decreases myocardial oxygen demand

Question 4

MORPHINE SULFATE

Pharmacokinetics

Answer 4

Onset of Action = Immediate IV, 15-30 minutes IM

Peak Effects = 20 minutes IV, 30-60 minutes IM

Duration of Effect = 2-7 hours

Half-Life = 1-7 hours

Question 5

MORPHINE SULFATE

Indications/Field Use:

Answer 5

• Severe pain/anxiety associated with MI, kidney stones, burns
• Pulmonary edema

Question 6

MORPHINE SULFATE

Contraindications:

Answer 6

• Hypovolemia or hypotension
• Undiagnosed head injury / AMS
• Hypersensitivity to morphine, codeine, percodan
• COPD/compromised respiratory status

Question 7

MORPHINE SULFATE

Side Effects/Adverse Reactions:

Answer 7

• N+V
• HA
• abd cramps
• blurred vision
• constricted pupils
• AMS
• respiratory depression

Question 8

MORPHINE SULFATE

ADULT DOSE:

Answer 8

(ADULT): 2-10mg IV initial, then 2mg every few min until relief of pain

Question 9

MORPHINE SULFATE

PEDI DOSE:

Answer 9

PEDI: 0.1mg/kg slow IVP (IO)

Question 10

MORPHINE SULFATE

Precautions:

Answer 10

Causes respiratory depression in high doses, have Narcan available

Question 11

MORPHINE SULFATE

Drug-Drug Interactions:

Answer 11

Additive effects (CNS depression) when given with:

• antihistamines
• antiemetics
• sedatives
• hypnotics
• barbiturates
• alcohol